US 11,987,618 B2
Camelidae single-domain antibodies against Yersinia pestis and methods of use
Camilla A Mauzy, Enon, OH (US); and Serge Victor Marie Muyldermans, Brussels (BE)
Assigned to The Government of the United States of America as Represented by the Secretary of the Air Force, Wright-Patterson AFB, OH (US)
Filed by Government of the United States as represented by the Secretary of the Air Force, Wright-Patterson AFB, OH (US)
Filed on Jan. 5, 2021, as Appl. No. 17/141,477.
Application 17/141,477 is a continuation of application No. 16/023,723, filed on Jun. 29, 2018, granted, now 11,339,208.
Application 16/023,723 is a continuation of application No. 13/906,386, filed on May 31, 2013, abandoned.
Claims priority of provisional application 61/653,488, filed on May 31, 2012.
Prior Publication US 2021/0147515 A1, May 20, 2021
Int. Cl. C07K 16/12 (2006.01)
CPC C07K 16/1228 (2013.01) 2 Claims
 
1. A single-domain antibody against Yersinia pestis (Y. pestis) LcrV protein comprising:
a first framing region (“FR”) sequence comprising SEQ ID No:97 or SEQ ID No:98;
a first complementarity determining region (“CDR”) sequence comprising SEQ ID No:22;
a second FR sequence comprising SEQ ID No:116, the first CDR sequence being positioned between the first FR sequence and the second FR sequence;
a second CDR sequence comprising SEQ ID No:49;
a third FR sequence comprising SEQ ID No: 141, the second CDR sequence being positioned between the second FR sequence and the third FR sequence;
a third CDR sequence comprising SEQ ID No.73; and
a fourth FR sequence comprising SEQ ID No:148, the third CDR sequence being positioned between the third FR sequence and the fourth FR sequence.