	US 11,987,615 B2
	Modified immunoglobulins
Yuan Guo, Beijing (CN); Baihong Liu, Beijing (CN); Yi Yang, Beijing (CN); and Yuelei Shen, Beijing (CN)
Assigned to Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing (CN)
Filed by Biocytogen Pharmaceuticals (Beijing) Co., Ltd., Beijing (CN)
Filed on Jul. 29, 2022, as Appl. No. 17/877,612.
Application 17/877,612 is a continuation of application No. PCT/CN2021/089649, filed on Apr. 25, 2021.
Claims priority of application No. PCT/CN2020/087036 (WO), filed on Apr. 26, 2020; application No. PCT/CN2021/073085 (WO), filed on Jan. 21, 2021; and application No. PCT/CN2021/085181 (WO), filed on Apr. 2, 2021.
Prior Publication US 2023/0041757 A1, Feb. 9, 2023
Int. Cl. C07K 16/00 (2006.01); C07K 14/52 (2006.01)

CPC C07K 16/00 (2013.01) [C07K 14/52 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/622 (2013.01); C07K 2319/00 (2013.01)]

17 Claims

1. A nucleic acid encoding a polypeptide complex comprising:

a first polypeptide comprising a first CH3 domain,

a second polypeptide comprising a second CH3 domain;

wherein a third polypeptide is linked to a first amino acid residue and a second amino acid residue of the first CH3 domain, wherein:

(1) the first amino acid residue is at position 358 of the first CH3 domain according to EU numbering, and the second amino acid residue is at position 359 of the first CH3 domain according to EU numbering,

(2) the first amino acid residue is at position 359 of the first CH3 domain according to EU numbering, and the second amino acid residue is at position 360 of the first CH3 domain according to EU numbering,

(3) the first amino acid residue is at position 360 of the first CH3 domain according to EU numbering, and the second amino acid residue is at position 361 of the first CH3 domain according to EU numbering, or

(4) the first amino acid residue is at position 361 of the first CH3 domain according to EU numbering, and the second amino acid residue is at position 362 of the first CH3 domain according to EU numbering.