US 11,987,614 B2
Polymeric forms of H-NOX proteins
Gregory Kapp, San Francisco, CA (US); Laura Serwer, Brisbane, CA (US); Natacha Le Moan, San Francisco, CA (US); and Stephen P. L. Cary, San Mateo, CA (US)
Assigned to OMNIOX, INC., San Carlos, CA (US)
Filed by Omniox, Inc., San Carlos, CA (US)
Filed on Aug. 9, 2021, as Appl. No. 17/397,577.
Application 16/931,736 is a division of application No. 16/450,913, filed on Jun. 24, 2019, granted, now 10,766,947, issued on Sep. 8, 2020.
Application 17/397,577 is a continuation of application No. 16/931,736, filed on Jul. 17, 2020, granted, now 11,117,952.
Application 16/450,913 is a continuation of application No. 14/759,635, granted, now 10,385,116, issued on Aug. 20, 2019, previously published as PCT/US2013/020602, filed on Jan. 7, 2013.
Prior Publication US 2022/0048977 A1, Feb. 17, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07H 21/00 (2006.01); A61K 38/16 (2006.01); A61K 38/41 (2006.01); A61K 45/06 (2006.01); A61N 5/10 (2006.01); C07K 14/795 (2006.01); G01N 33/53 (2006.01); G01N 33/574 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/795 (2013.01) [A61K 38/164 (2013.01); A61K 38/41 (2013.01); A61K 45/06 (2013.01); A61N 5/10 (2013.01); G01N 33/53 (2013.01); G01N 33/57407 (2013.01); A61K 38/00 (2013.01); A61N 2005/1098 (2013.01); C07K 2319/21 (2013.01); G01N 2800/52 (2013.01); Y02A 50/30 (2018.01)] 15 Claims
 
1. A method of delivering oxygen to a brain tumor in an individual with a brain cancer comprising administering an effective amount of a trimeric H-NOX protein comprising three H-NOX monomers, to the individual.