	US 11,987,606 B2
	Compositions and methods for enhancing an immune response
Tzyy-Choou Wu, Stevenson, MD (US); Chih-Ping Mao, Baltimore, MD (US); and Chien-Fu Hung, Timonium, MD (US)
Assigned to The Johns Hopkins University, Baltimore, MD (US)
Appl. No. 15/555,613
Filed by The Johns Hopkins University, Baltimore, MD (US)
PCT Filed Mar. 4, 2016, PCT No. PCT/US2016/020874 § 371(c)(1), (2) Date Sep. 5, 2017, PCT Pub. No. WO2016/141284, PCT Pub. Date Sep. 9, 2016.
Claims priority of provisional application 62/128,327, filed on Mar. 4, 2015.
Prior Publication US 2018/0037621 A1, Feb. 8, 2018
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/00 (2006.01); A61K 35/17 (2015.01); A61K 39/385 (2006.01); C07K 14/00 (2006.01); C07K 14/47 (2006.01); C07K 14/74 (2006.01); C07K 14/77 (2006.01); C12N 15/62 (2006.01); A61K 35/12 (2015.01)

CPC C07K 14/4721 (2013.01) [A61K 35/17 (2013.01); A61K 39/00 (2013.01); A61K 39/0005 (2013.01); A61K 39/385 (2013.01); C07K 14/00 (2013.01); C07K 14/47 (2013.01); C07K 14/70539 (2013.01); C07K 14/77 (2013.01); C12N 15/62 (2013.01); A61K 2035/124 (2013.01); A61K 2039/57 (2013.01); A61K 2039/6031 (2013.01); A61K 2039/605 (2013.01); C07K 2319/00 (2013.01)]

13 Claims

1. A compound comprising: (a) a soluble Major Histocompatibility Complex (MHC) molecule; and (b) a dynamic anchor comprising Annexin V, wherein the MHC molecule comprises a class I MHC alpha chain comprising the amino acid sequence set forth in SEQ ID NO: 17 or SEQ ID NO: 18, and a β-2 microglobulin polypeptide comprising the sequence set forth in SEQ ID NO: 5 or SEQ ID NO: 6, and

wherein the dynamic anchor comprises the amino acid sequence depicted in SEQ ID NO: 1 or 2.