CPC C07F 9/6561 (2013.01) [A61K 9/08 (2013.01); A61K 9/4825 (2013.01); C07D 471/02 (2013.01); C07F 9/65583 (2013.01); C07F 9/6584 (2013.01)] | 21 Claims |
1. A compound, or pharmaceutically acceptable salt, solvate, or N-oxide thereof, wherein the compound has a structure of Formula (IB):
![]() wherein:
A is N;
B is C—R;
R is selected from halogen, amino, or optionally substituted C1-C3 alkyl;
R1 is selected from halogen, cyano, optionally substituted C1-C3 alkyl, optionally substituted C3-C5 cycloalkyl, optionally substituted C2-C3 alkenyl, or optionally substituted C2-C3 alkynyl;
R2 is L-G; wherein L is a bond, —O—, —NH—, —NH (optionally substituted C1-C3 alkylene)-, optionally substituted C1-C3 alkylene, or optionally substituted cyclopropyl; and G is an optionally substituted C6 aryl, or optionally substituted 5- or 6-membered heteroaryl;
R3 is hydroxy or optionally substituted C1-C6 alkyl;
R4 is hydroxy or optionally substituted C1-C6 alkyl; or R3 and R4 join to form optionally substituted phosphorus-containing 3- to 8-membered heterocyclyl;
each R5 and R6 is independently selected from hydrogen, halogen, or optionally substituted C1-C3 alkyl;
W is N;
X is C—R8;
Y is C—R9;
Z is C—R10;
R8 is selected from hydrogen, halogen, —CN, optionally substituted C1-C3 alkyl, optionally substituted C1-C3 alkoxy, or —NH (optionally substituted C1-C3 alkyl); and
each R9 and R10 is independently selected from hydrogen, halogen, —CN, optionally substituted C1-C3 alkyl, optionally substituted C3-C7 cycloalkyl, optionally substituted C1-C3 alkoxy, or —NH (optionally substituted C1-C3 alkyl).
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