US 11,987,595 B2
Fluorogenic probe using a Mislow-Evans rearrangement for real-time imaging of hydrogen peroxide
Kazunori Koide, Pittsburgh, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed on Oct. 29, 2021, as Appl. No. 17/514,356.
Claims priority of provisional application 63/107,733, filed on Oct. 30, 2020.
Prior Publication US 2022/0135604 A1, May 5, 2022
Int. Cl. C07F 11/00 (2006.01); G01N 1/30 (2006.01); G01N 21/64 (2006.01); G01N 33/84 (2006.01)
CPC C07F 11/00 (2013.01) [G01N 21/643 (2013.01); G01N 33/84 (2013.01); G01N 2021/6439 (2013.01)] 19 Claims
 
1. A compound having the structure:

OG Complex Work Unit Chemistry
wherein:
R1 is a fluorescent dye moiety that does not fluoresce when incorporated in the compound or fluoresces with a different intensity or peak wavelength when incorporated in the compound; and
R2 is optionally substituted and is alkyl, heteroalkyl, aryl, heteroaryl, or any combination of the proceeding.