CPC C07D 471/04 (2013.01) [A61K 45/06 (2013.01); A61P 35/04 (2018.01); C07D 235/10 (2013.01); C07D 249/18 (2013.01)] | 20 Claims |
1. A compound of formula (I), or a pharmaceutically acceptable salt thereof,
![]() wherein,
![]() is
![]() X1 is N or CRx1;
X2 is N;
X3 is N or CRx3;
Z is aryl or heteroaryl, wherein the aryl and the heteroaryl are optionally substituted with 1, 2, 3, or 4RZ;
RA1 and RA2 are haloalkyl, halogen, oxo, cyano, nitro, —OH, alkoxy, or —C(O)alkyl;
Rx1 and Rx3 are independently selected from the group consisting of hydrogen, halogen, nitro, alkyl, cyano, haloalkyl, alkoxyalkyl, heteroalkyl, alkenyl, alkynyl, heterocycle, carboxyl, heterocyclealkyl, —OH, alkoxy, —OR4, —SR5, —NR6R7, and —NR8—SO2—R9;
Rz at each occurrence is independently selected from the group consisting of halogen, nitro, alkyl, cyano, haloalkyl, alkoxyalkyl, heteroalkyl, alkenyl, alkynyl, heterocycle, carboxyl, heterocyclealkyl, —OH, alkoxy, —OR4, —SR5, —NR6R7, —SO2—R9, and —NR8—SO2—R9;
R4 is selected from —C(O)-alkyl, —C(O)-alkenyl, —C(O)-heteroalkyl, —C(O)-heteroaryl, —C(O)-alkoxyalkyl, —C(O)—O-heteroalkyl, —C(O)—O-heteroaryl, —C(O)—O-alkyl, —C(O)—O-alkenyl, and —C(O)—O— alkoxyalkyl;
R5, R6 and R7 are each independently selected from hydrogen, alkyl, —C(O)-alkyl, —C(O)—O-alkyl, —C(O)—O-alkenyl, —C(O)-alkoxyalkyl, —C(O)—NH-alkyl, —C(O)-heterocycle, -alkenyl, alkynyl, and heteroalkyl;
R8 is selected from hydrogen and alkyl; and
R9 is selected from hydrogen, alkyl, aryl, heteroaryl, arylalkyl, heterocycle and heteroarylalkyl,
provided that Z is not benzo[d]thiazole or substituted benzo[d]thiazole.
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