CPC C07D 401/14 (2013.01) [C07D 403/14 (2013.01)] | 3 Claims |
1. A compound of formula (Ic):
![]() or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from H, halo, aryl, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, and (C2-C6)alkynyl, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, and (C2-C6)alkynyl of R1 is optionally substituted with one or more groups independently selected from the group consisting of halo, oxo, —OH, cyano, (C3-C6)cycloalkyl, and (C1-C6)alkoxy; and wherein any aryl of R1 is optionally substituted with one or more groups independently selected from the group consisting of halo, —OH, cyano, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio and (C2-C6)alkanoyloxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C2-C6)alkenyl, (C2-C6)alkynyl, (C1-C6)alkanoyl, (C1-C6)alkoxycarbonyl, (C1-C6)alkylthio and (C2-C6)alkanoyloxy group on an aryl of R1 is optionally substituted with one or more groups independently selected from the group consisting of halo and —OH;
R2 is aryl that is optionally substituted with one or more groups independently selected from the group consisting of halo, —OH, cyano, (C1-C6)alkyl, (C3-C6)cycloalkyl, and (C1-C6)alkoxy, wherein any (C1-C6)alkyl, (C3-C6)cycloalkyl, and (C1-C6)alkoxy of R2 is optionally substituted with one or more groups independently selected from the group consisting of halo, and (C1-C6)alkoxy;
R3 is selected from the group consisting of H, —C(═N(Ra))NRaRb, and (C1-C6)alkyl that is optionally substituted with one or more groups independently selected from the group consisting of halo, —OH, cyano, (C3-C6)cycloalkyl, (C1-C6)alkoxy, —C(═N(Ra))NRaRb, and —NRaRb;
each Ra and Rb is independently selected from the group consisting of H, (C1-C6)alkyl, (C1-C6)alkanoyl, and (C3-C6)cycloalkyl; or Ra and Rb together with the nitrogen to which they are attached form a 4-6 membered ring heterocycle;
F is O, S, or NRc;
G is CH or N; and
Rc is H or (C1-C6)alkyl.
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