CPC C07D 401/04 (2013.01) [A61P 35/00 (2018.01); C07D 471/04 (2013.01)] | 16 Claims |
1. A compound having the general Formula (I):
![]() wherein
R1 is selected from the group consisting of C1-6-alkyl, C1-3-alkoxy-C1-3-alkyl, and C1-3-alkylamino-C1-3-alkyl, wherein each said C1-6-alkyl, C1-3-alkoxy-C1-3-alkyl, and C1-3-alkylamino-C1-3-alkyl is optionally substituted by one or more groups independently selected from the group consisting of OH and halogen;
R2 is selected from the group consisting of —CO—R5, —CONH—R5, and
—COO—R5;
R3 is 1,1-dioxothietan-3-yl, which is optionally substituted by one or more groups independently selected from the group consisting of C1-4-alkyl,
—OH, and halogen;
R4 is each independently selected from the group consisting of H and C1-4-alkyl;
n is 4; and
R5 is selected from the group consisting of —H, C1-6-alkyl, C1-6-alkoxy, C1-3-alkoxy-C1-3-alkyl, C1-6-alkylthio, C1-3-alkylthio-C1-3-alkyl, C1-3-alkylamino-C1-3-alkyl, C6-10-aryl, 4- to 10-membered heterocycloalkyl,
C3-10-cycloalkyl and 5- to 10-membered heteroaryl, wherein said C1-6-alkyl, C1-6-alkoxy, C1-3-alkoxy-C1-3-alkyl, C1-6-alkylthio, C1-3-alkylthio-C1-3-alkyl, C1-3-alkylamino-C1-3-alkyl, C6-10-aryl, 4- to 10-membered heterocycloalkyl, C3-10-cycloalkyl and 5- to 10-membered heteroaryl is optionally substituted by one or more groups independently selected from the group consisting of C1-4-alkyl, —OH, halogen, —CO—N(R4)2, —N(R4)2,
—CO—R4, —COO—R4, —N3, —NO2, and —CN;
or a physiologically functional derivative, solvate or salt thereof.
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