US 11,987,568 B2
Allosteric inhibitor of WEE1 kinase
Nupam Mahajan, Clayton, MO (US); and Nicholas Lawrence, Tampa, FL (US)
Assigned to H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., Tampa, FL (US)
Appl. No. 17/265,649
Filed by H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., Tampa, FL (US)
PCT Filed Aug. 2, 2019, PCT No. PCT/US2019/044922
§ 371(c)(1), (2) Date Feb. 3, 2021,
PCT Pub. No. WO2020/028814, PCT Pub. Date Feb. 6, 2020.
Claims priority of provisional application 62/714,351, filed on Aug. 3, 2018.
Prior Publication US 2021/0309630 A1, Oct. 7, 2021
Int. Cl. C07D 333/38 (2006.01)
CPC C07D 333/38 (2013.01) 5 Claims
 
1. A compound having a structure below:

OG Complex Work Unit Chemistry
wherein:
R1 is —NH2 or a salt thereof; and
R2 and R3 are independently for each occurrence selected from hydrogen, hydroxyl, C1-C6 alkyl, halogen, amino, C1-6 alkyl amine, or a salt thereof.