US 11,987,566 B2
Nerve damage preventing and nerve protecting compounds, preparation method thereof, pharmaceutical composition thereof, and their use
Lain-Tze Lee, Hsinchu (TW); Hui-Ping Tsai, Hsinchu (TW); Yi-Wen Lin, Taoyuan (TW); Shu-Fen Huang, Taoyuan (TW); Shih-Hung Liu, Taoyuan (TW); Chin-Wei Liu, Taoyuan (TW); Pi-Tsan Huang, Hsinchu (TW); and Mei-Hui Chen, Hsinchu (TW)
Assigned to GENHEALTH PHARMA CO., LTD., Taipei (TW)
Filed by GENHEALTH PHARMA CO., LTD., Taipei (TW)
Filed on Jan. 28, 2022, as Appl. No. 17/587,268.
Prior Publication US 2023/0242501 A1, Aug. 3, 2023
Int. Cl. C07D 317/64 (2006.01); A61P 25/28 (2006.01); C07D 317/68 (2006.01); C07D 405/12 (2006.01); C07D 409/12 (2006.01)
CPC C07D 317/64 (2013.01) [A61P 25/28 (2018.01); C07D 317/68 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01)] 11 Claims
 
1. A compound represented by the following Formula (I):

OG Complex Work Unit Chemistry
wherein, R is a hydrogen atom or an unsubstituted alkyl group having 1 to 6 carbon atoms;
L1 is an unsubstituted alkylene group having 1 to 6 carbon atoms, and L2 is an unsubstituted alkylene group having 1 to 6 carbon atoms or an unsubstituted arylene group having 6 to 18 carbon atoms;
Y is an acyloxy group or an amide group;
Z is a carboxyl group, pyrocatechin, an unsubstituted ester group having 1 to 6 carbon atoms, 2-methoxybenzenesulfonamide, 2,3-dimethyl-1-phenyl-5-pyrazolone, or 2-methyl-4-cyanothiophene; and
n1 and n2 are each independently 0 or 1.