US 11,987,555 B2
Malassezin and analogs thereof as skin brightening agents
Michael Einziger, Malibu, CA (US); and Ann Marie Simpson, Malibu, CA (US)
Assigned to VERSICOLOR TECHNOLOGIES, LLC, Santa Monica, CA (US)
Filed by Versicolor Technologies, LLC, Santa Monica, CA (US)
Filed on Aug. 23, 2021, as Appl. No. 17/409,702.
Application 17/409,702 is a division of application No. 16/121,353, filed on Sep. 4, 2018, granted, now 11,104,644.
Application 16/121,353 is a division of application No. 15/455,932, filed on Mar. 10, 2017, granted, now 10,131,631, issued on Nov. 20, 2018.
Claims priority of provisional application 62/306,468, filed on Mar. 10, 2016.
Prior Publication US 2021/0380532 A1, Dec. 9, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 209/12 (2006.01); A61K 8/49 (2006.01); A61Q 19/02 (2006.01); C07D 487/04 (2006.01)
CPC C07D 209/12 (2013.01) [A61K 8/492 (2013.01); A61Q 19/02 (2013.01); C07D 487/04 (2013.01)] 15 Claims
 
1. A method for brightening skin in a subject comprising:
contacting the subject with a composition comprising:
(a) a compound having the structure of formula (II):

OG Complex Work Unit Chemistry
wherein:
R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, and R11 are independently selected from the group consisting of hydrogen and methyl;
or a cosmetically or pharmaceutically acceptable salt thereof,
(b) a cosmetically or pharmaceutically acceptable vehicle, diluent or carrier, and
(c) one or more ingredients selected from the group consisting of perfumes, estrogen, vitamin A, vitamin C, vitamin E, pyruvic acid, lactic acid, glycolic acid, lanolin, vaseline, aloe vera, methyl paraben, propyl paraben, and pigments,
wherein the composition is a cosmetic composition.