CPC C07D 207/26 (2013.01) [C07D 207/416 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 413/14 (2013.01)] | 16 Claims |
1. A method to treat a viral infection, which comprises administering to a subject in need of such treatment a compound of Formula (I):
or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate, or hydrate thereof; wherein:
Z is selected from —CH2CN, —C(═O)—CH═CH2, and —CH(OH)SO3− (and an associated cation, optionally wherein the cation is Na+);
L is —C(═O)—NH—;
R1 is
R2 is selected from C1-6 alkyl, 3-7 membered cycloalkyl, C1-3 alkyl-(3-7 membered cycloalkyl), and (3-7 membered cycloalkyl)-C1-3 alkyl, each of which is optionally substituted with up to three groups selected from halo, CN, C1-3 alkyl, C1-6 alkoxy, C1-3 haloalkyl, and C1-3 haloalkoxy;
R3 is H or C1-4 alkyl;
each R* is independently selected from C1-3 alkyl, C1-3 alkoxy, C1-3 haloalkyl, CN, halo, and —OH;
m is an integer from 0 to 2; and
n is an integer from 0 to 4 wherein the viral infection is a coronavirus infection.
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