US 11,986,824 B2
System and method for immune activity determination
Henry Tat Kwong Tse, San Francisco, CA (US); Ajay M. Shah, San Francisco, CA (US); Lionel Guillou, San Francisco, CA (US); Roya Sheybani, San Francisco, CA (US); Christopher Dahlberg, San Francisco, CA (US); and Anne E. Jensen, San Francisco, CA (US)
Assigned to CytoVale Inc., San Francisco, CA (US)
Filed by CytoVale Inc., San Francisco, CA (US)
Filed on Aug. 13, 2021, as Appl. No. 17/401,627.
Application 17/401,627 is a continuation of application No. 16/943,716, filed on Jul. 30, 2020, granted, now 11,123,734.
Claims priority of provisional application 62/881,283, filed on Jul. 31, 2019.
Prior Publication US 2021/0370301 A1, Dec. 2, 2021
Int. Cl. B01L 3/00 (2006.01); G06N 3/02 (2006.01); G06T 7/00 (2017.01)
CPC B01L 3/502761 (2013.01) [B01L 3/502715 (2013.01); B01L 3/502746 (2013.01); B01L 3/502753 (2013.01); G06N 3/02 (2013.01); G06T 7/0012 (2013.01); B01L 2200/0631 (2013.01); B01L 2200/0652 (2013.01); B01L 2200/0668 (2013.01); B01L 2200/0684 (2013.01); B01L 2200/0694 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0877 (2013.01); B01L 2300/0887 (2013.01); B01L 2300/185 (2013.01); B01L 2400/0409 (2013.01); B01L 2400/0415 (2013.01); B01L 2400/0436 (2013.01); G06T 2207/30024 (2013.01); G06T 2207/30104 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A method comprising:
receiving a plurality of blood cells from a patient;
for each blood cell of the plurality of blood cells, determining biophysical parameters based on an oscillation of the blood cell as the blood cell is deformed, wherein the oscillation occurs while the blood cell is moving along a channel, wherein the oscillation occurs in a direction perpendicular to a longitudinal axis of the channel;
computing an index from the biophysical parameters using a logistic regression; and
within at most a threshold time of receiving the plurality of blood cells, determining an immune activation of the patient based on the index.