	US 11,986,815 B2
	Processes and systems for producing and/or purifying gallium-68
Brigitte Guerin, Westbury (CA); Sebastien Tremblay, Sherbrooke (CA); Samia Ait-Mohand, Sherbrooke (CA); and Aiman H. Alnahwi, Dammam (SA)
Assigned to SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES SANTE ET HUMAINES S.E.C., Sherbrooke (CA)
Appl. No. 17/413,146
Filed by SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUÉE SOCPRA SCIENCES ET GÉNIE S.E.C., Sherbrooke (CA)
PCT Filed Dec. 10, 2019, PCT No. PCT/CA2019/051777 § 371(c)(1), (2) Date Jun. 11, 2021, PCT Pub. No. WO2020/118426, PCT Pub. Date Jun. 18, 2020.
Claims priority of provisional application 62/777,994, filed on Dec. 11, 2018.
Prior Publication US 2022/0044835 A1, Feb. 10, 2022
Int. Cl. B01J 47/026 (2017.01); A61B 6/03 (2006.01); A61K 51/08 (2006.01); B01J 39/26 (2006.01); G21G 1/00 (2006.01); G21G 1/10 (2006.01)

CPC B01J 47/026 (2013.01) [A61K 51/083 (2013.01); B01J 39/26 (2013.01); A61B 6/037 (2013.01); G21G 2001/0021 (2013.01); G21G 1/10 (2013.01)]

11 Claims

1. A process for purifying ⁶⁸Ga produced by cyclotron, the process comprising the steps of:

(a) providing a solution comprising a mixture of ⁶⁸Zn and ⁶⁸Ga;

(b) contacting the solution with a first chelating cation exchange column, the first chelating cation exchange column comprising a hydroxamate resin;

(c) washing the first chelating cation exchange column obtained after step (b) to obtain a washed first chelating cation exchange column;

(d) eluting the ⁶⁸Ga from the washed first chelating cation exchange column to obtain a first eluent;

(e) contacting the first eluent with a second copolymeric cation exchange column, the second copolymeric cation exchange column comprising a resin;

(f) washing the second copolymeric cation exchange column after step (e) to obtain a washed second copolymeric cation exchange column; and

(g) eluting the ⁶⁸Ga from the washed second copolymeric cation exchange column to obtain a second eluent comprising purified ⁶⁸Ga.