US 11,986,787 B2
Disposable bioreactor systems and related methods
Mark D. Selker, Los Altos Hills, CA (US); and Barbara Paldus, Atherton, CA (US)
Assigned to Finesse Solutions, Inc., Santa Clara, CA (US)
Filed by Finesse Solutions, Inc., Santa Clara, CA (US)
Filed on Sep. 28, 2020, as Appl. No. 17/034,575.
Application 17/034,575 is a continuation of application No. 15/828,324, filed on Nov. 30, 2017, granted, now 10,821,409.
Application 15/828,324 is a continuation of application No. 12/008,447, filed on Jan. 10, 2008, granted, now 9,868,095, issued on Jan. 16, 2018.
Claims priority of provisional application 60/927,274, filed on May 2, 2007.
Prior Publication US 2021/0008512 A1, Jan. 14, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. B01F 3/04 (2006.01); B01F 11/00 (2006.01); B01F 15/00 (2006.01); B01F 23/231 (2022.01); B01F 31/22 (2022.01); B01F 31/23 (2022.01); B01F 31/25 (2022.01); B01F 35/51 (2022.01); B01F 35/513 (2022.01); B01F 35/53 (2022.01); C12M 1/00 (2006.01); C12M 3/04 (2006.01); C12M 3/06 (2006.01)
CPC B01F 31/25 (2022.01) [B01F 23/23121 (2022.01); B01F 31/22 (2022.01); B01F 31/23 (2022.01); B01F 35/51 (2022.01); B01F 35/513 (2022.01); B01F 35/53 (2022.01); B01F 35/531 (2022.01); C12M 23/02 (2013.01); C12M 23/28 (2013.01); C12M 27/10 (2013.01); C12M 27/16 (2013.01); C12M 27/20 (2013.01)] 12 Claims
OG exemplary drawing
 
1. An apparatus comprising:
(a) a hollow toroidal bioreactor vessel having an interior bounded by an inner surface, a textured surface being arranged on at least a portion of the inner surface, the textured surface having a sinusoidal shape pattern and being comprised of a plurality of upstanding protuberances, the toroidal bioreactor vessel further comprising a plurality of tubes coupled to at least a portion of the inner surface of the toroidal bioreactor vessel, wherein the plurality of tubes are configured for sparging gas into said toroidal bioreactor vessel, wherein one or more of the plurality of tubes is coupled to one or more of a bottom, a top, or a side-wall of the toroidal bioreactor vessel; and
(b) a drive including a motor driven platform, wherein when the toroidal bioreactor vessel rests on the motor driven platform and a fluid is disposed within the interior of the toroidal bioreactor vessel, the drive is configured to move the platform orbitally such that there is a resonant frequency traveling wave of the fluid orbiting in one direction in the interior of the toroidal bioreactor vessel when a particular orbital speed is imparted to the toroidal bioreactor vessel, and
wherein the orbiting direction of the traveling wave of the fluid is parallel to a direction of periodic oscillation of the sinusoidal shape pattern of the textured surface,
wherein at least some of the plurality of tubes extend through the plurality of upstanding protuberances of the textured surface.