US 11,986,670 B2
System and method for multi-site radiotherapy
Steven J Chmura, Chicago, IL (US); Shan Lu, Chicago, IL (US); and Ralph R. Weichselbaum, Chicago, IL (US)
Assigned to THE UNIVERSITY OF CHICAGO, Chicago, IL (US)
Appl. No. 17/274,908
Filed by THE UNIVERSITY OF CHICAGO, Chicago, IL (US)
PCT Filed Sep. 18, 2019, PCT No. PCT/US2019/051710
§ 371(c)(1), (2) Date Mar. 10, 2021,
PCT Pub. No. WO2020/061179, PCT Pub. Date Mar. 26, 2020.
Claims priority of provisional application 62/733,263, filed on Sep. 19, 2018.
Prior Publication US 2022/0047892 A1, Feb. 17, 2022
Int. Cl. A61N 5/10 (2006.01)
CPC A61N 5/103 (2013.01) [A61N 5/1077 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A method of radiating a plurality of masses in a patient, the method comprising:
receiving a three-dimensional model of the patient, the three-dimensional model including respective locations of a plurality of organs at risk;
receiving a set of locations in the three-dimensional model corresponding to the plurality of masses;
receiving respective prescribed radiation dosages for the plurality of masses;
receiving respective radiation limits for the plurality of organs at risk;
computing a candidate set of beams having respective beam paths that travel through at least one of the plurality of masses;
scoring the candidate set of beams based on respective dosages provided to the plurality of masses, respective dosages provided to the plurality of organs at risk, and beams in a set of selected beams for treatment, wherein scoring the candidate set of beams comprises:
improving a score of a candidate beam according to a first dosage provided by the candidate beam to the plurality of masses; and
penalizing the score of the candidate beam according to a second dosage provided by the candidate beam to at least one of the plurality of organs at risk;
adding a best-scoring beam among the candidate set of beams to the set of selected beams; and
radiating the plurality of masses using the set of selected beams.