US 11,986,666 B2
Illumination devices for inducing biological effects
Adam Cockrell, Durham, NC (US); Jacob Kocher, Durham, NC (US); David T. Emerson, Durham, NC (US); Michael John Bergmann, Atlanta, GA (US); Thomas Matthew Womble, Wake Forest, NC (US); Antony Paul van de Ven, Nongkae (TH); Nathan Stasko, Chapel Hill, NC (US); F. Neal Hunter, Durham, NC (US); and Rebecca McDonald, Chapel Hill, NC (US)
Assigned to KNOW Bio, LLC, Morrisville, NC (US)
Filed by KNOW Bio, LLC, Durham, NC (US)
Filed on Feb. 11, 2021, as Appl. No. 17/173,457.
Application 17/173,457 is a continuation in part of application No. 17/162,259, filed on Jan. 29, 2021.
Application 17/162,259 is a continuation in part of application No. 17/117,889, filed on Dec. 10, 2020, granted, now 11,147,984.
Claims priority of provisional application 63/123,631, filed on Dec. 10, 2020.
Claims priority of provisional application 63/075,010, filed on Sep. 4, 2020.
Claims priority of provisional application 63/074,970, filed on Sep. 4, 2020.
Claims priority of provisional application 63/065,357, filed on Aug. 13, 2020.
Claims priority of provisional application 62/991,903, filed on Mar. 19, 2020.
Prior Publication US 2021/0290971 A1, Sep. 23, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 5/06 (2006.01)
CPC A61N 5/0603 (2013.01) [A61N 5/062 (2013.01); A61N 5/0624 (2013.01); A61N 2005/0604 (2013.01); A61N 2005/0606 (2013.01); A61N 2005/0658 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method comprising:
providing an illumination device configured to emit light with a light characteristic comprising a peak wavelength in a range from 410 nanometers (nm) to 440 nm and a full width half maximum that is less than or equal to 40 nm, the illumination device comprising a light source, a light guide forming a hollow light transmissive pathway configured to receive the light from the light source, and a light guide positioner configured such that the light guide extends through the light guide positioner to secure at least a portion of the light guide past the light guide positioner within a user's oral cavity; and
irradiating tissue accessible from the user's oral cavity with the light at a dose up to 120 joules per square centimeter (J/cm2) to induce a biological effect, wherein the biological effect comprises altering a local immune response by upregulating interleukin 1 alpha (IL-1α) molecules and downregulating interleukin 6 (IL-6) molecules within the tissue.