US 11,986,660 B2
Method and system for improving stimulation of excitable tissue
Jens Schouenborg, Lund (SE); and Hjalmar Bjartmarz, Höllviken (SE)
Assigned to NEURONANO AB, Karlshamn (SE)
Filed by NEURONANO AB, Karlshamn (SE)
Filed on Dec. 13, 2021, as Appl. No. 17/549,065.
Application 17/549,065 is a continuation of application No. 15/737,236, granted, now 11,198,003, previously published as PCT/SE2016/050698, filed on Jul. 7, 2016.
Claims priority of application No. 1551013-4 (SE), filed on Jul. 10, 2015; and application No. PCT/SE2016/050534 (WO), filed on Jun. 3, 2016.
Prior Publication US 2022/0096838 A1, Mar. 31, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61B 5/24 (2021.01); A61B 5/377 (2021.01); A61N 1/05 (2006.01); A61N 1/372 (2006.01); A61N 1/378 (2006.01)
CPC A61N 1/36132 (2013.01) [A61B 5/24 (2021.01); A61B 5/377 (2021.01); A61N 1/0534 (2013.01); A61N 1/36064 (2013.01); A61N 1/36067 (2013.01); A61N 1/36071 (2013.01); A61N 1/36085 (2013.01); A61N 1/36096 (2013.01); A61N 1/36139 (2013.01); A61N 1/36175 (2013.01); A61N 1/36185 (2013.01); A61N 1/37241 (2013.01); A61N 1/37247 (2013.01); A61N 1/378 (2013.01); A61B 2562/0209 (2013.01); A61B 2562/046 (2013.01); A61N 1/05 (2013.01); A61N 1/36114 (2013.01)] 37 Claims
OG exemplary drawing
 
1. A method for optimization of a stimulation specificity and an energy consumption of implanted electrodes in excitable tissue of a patient, the method comprising:
electrically stimulating excitable tissue between each of one or more different combinations of electrode pairs in a cluster of electrodes, or
electrically stimulating excitable tissue between each of one or more different combinations of electrode pairs in two or up to 50 clusters of electrodes, each cluster containing 1-15 electrodes, wherein two electrodes of the electrode pairs do not belong to a same cluster;
wherein each of the electrodes is located on a physically separated entity, such that the tissue surrounds and separates each electrode from all other electrodes, thereby allowing tissue between the electrodes to be stimulated;
wherein the electrodes are microelectrodes having a diameter of less than 100 μm;
choosing an electrode pair or pairs which give rise to a lowest energy consumption while still giving a therapeutic effect, or
assigning each electrode pair a value related to the information provided by the patient and the energy consumption, and choosing the electrode pair or pairs which give(s) rise to a most favorable assigned value; and then
stimulating the chosen electrodes to treat or alleviate a neurological disease or condition of the patient.