US 11,986,647 B2
Treating autoinflammatory and mitochondrial diseases using an alternating electric field
Stuart Smith, Notts (GB); Lilach Avigdor, Haifa (IL); and Tali Voloshin-Sela, Haifa (IL)
Assigned to Novocure GmbH, Root (CH)
Filed by Novocure GmbH, Root (CH)
Filed on Jun. 25, 2021, as Appl. No. 17/358,258.
Application 17/358,258 is a continuation in part of application No. 17/333,509, filed on May 28, 2021.
Application 17/333,509 is a continuation of application No. 16/560,134, filed on Sep. 4, 2019, granted, now 11,020,585, issued on Jun. 1, 2021.
Claims priority of provisional application 63/045,980, filed on Jun. 30, 2020.
Claims priority of provisional application 63/045,378, filed on Jun. 29, 2020.
Claims priority of provisional application 63/045,390, filed on Jun. 29, 2020.
Claims priority of provisional application 62/728,174, filed on Sep. 7, 2018.
Prior Publication US 2021/0379362 A1, Dec. 9, 2021
Int. Cl. A61N 1/04 (2006.01); A61N 1/32 (2006.01); A61N 1/36 (2006.01)
CPC A61N 1/0456 (2013.01) [A61N 1/3616 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A method of treating an autoinflammatory disease in a target region of a subject's body, the method comprising:
positioning a plurality of electrodes in or on the subject's body, positioned with respect to the target region so that application of an AC voltage between the plurality of electrodes will impose an alternating electric field through tissue that is being affected by the autoinflammatory disease in the target region; and
applying an AC voltage between the plurality of electrodes for an interval of time, such that an alternating electric field is imposed through the tissue for the interval of time,
wherein the alternating electric field has a frequency and a field strength such that when the alternating electric field is imposed in the tissue for the interval of time, the alternating electric field inhibits inflammation in the tissue, wherein the alternating electric field has a frequency between 50 and 500 kHz.