US 11,986,627 B1
Intelligent pharmaceutical delivery system with non-concentric pumping mechanism to reduce flow anomaly and method of using
Stéphane Bibian, Cleveland Heights, OH (US); Sankar Barua, Stow, OH (US); and Tatjana Zikov, Cleveland Heights, OH (US)
Assigned to NeuroWave Systems Inc., Cleveland, OH (US)
Filed by NeuroWave Systems Inc., Cleveland Heights, OH (US)
Filed on Oct. 20, 2020, as Appl. No. 17/074,795.
Application 17/074,795 is a continuation of application No. 15/213,489, filed on Jul. 19, 2016, granted, now 10,842,932.
Application 15/213,489 is a continuation in part of application No. 14/874,736, filed on Oct. 5, 2015, granted, now 10,130,766, issued on Nov. 20, 2018.
Application 14/874,736 is a continuation in part of application No. 13/962,565, filed on Aug. 8, 2013, granted, now 11,565,042.
Claims priority of provisional application 62/338,129, filed on May 18, 2016.
Claims priority of provisional application 61/680,888, filed on Aug. 8, 2012.
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/369 (2021.01); A61M 5/142 (2006.01); A61M 5/168 (2006.01); A61M 5/172 (2006.01); A61M 19/00 (2006.01); A61M 21/00 (2006.01); F04B 43/12 (2006.01); G08B 5/36 (2006.01)
CPC A61M 5/1684 (2013.01) [A61M 5/14232 (2013.01); A61M 19/00 (2013.01); F04B 43/12 (2013.01); G08B 5/36 (2013.01); A61M 2005/16863 (2013.01); A61M 2205/14 (2013.01); A61M 2205/18 (2013.01); A61M 2205/332 (2013.01); A61M 2205/6063 (2013.01); A61M 2230/005 (2013.01); A61M 2230/10 (2013.01); F04B 43/1238 (2013.01); F04B 43/1253 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for delivering intravenous drugs and fluids to a subject, the system comprising:
an infusion pump comprising:
an administration set integrating a disposable cartridge comprising at least two rollers or roller elements, gears, a tube, and a pumping chamber having an entry opening, an exit opening, and a tubing groove having a groove wall with a non-concentric geometry against which the tube is being occluded by a passage of the at least two rollers or roller elements, and where the pumping chamber having the tubing groove having the groove wall with the non-concentric geometry is such that a distance between each of the at least two rollers or roller elements and the groove wall is adapted to reduce flow pulsation and occlusion of the infusion pump;
a pump module comprising a driving shaft adapted to cause the gears to rotate, the pump module adapted to allow the disposable cartridge to be inserted on to the pump module and locked into place; and
a physiological signal sensor adapted to acquire a physiological signal from the subject; and a controller adapted to control the infusion pump and administration of the intravenous drugs and fluids, the controller comprising a processor adapted for receiving the physiological signal from the physiological signal sensor and further comprising an algorithm adapted to perform real-time quantitative monitoring of the physiological signal,
wherein the infusion pump is adapted to progressively increase the occlusion at or near the entry opening and progressively decrease the occlusion at or near the exit opening and to reduce the flow pulsation.