US 11,986,597 B2
Nitric oxide generating systems for inhalation
Glenn Martin, Redford Township, MI (US); Andrew P. Hunt, Ann Arbor, MI (US); Maria Kim, Ann Arbor, MI (US); Mark E. Meyerhoff, Ann Arbor, MI (US); and Malcolm Kahn, Franklin Lakes, NJ (US)
Assigned to NOTA Laboratories, LLC, Ann Arbor, MI (US)
Filed by NOTA Laboratories, LLC, Ann Arbor, MI (US)
Filed on Feb. 23, 2021, as Appl. No. 17/182,868.
Application 17/182,868 is a continuation in part of application No. 16/846,063, filed on Apr. 10, 2020.
Claims priority of provisional application 62/891,129, filed on Aug. 23, 2019.
Prior Publication US 2021/0178106 A1, Jun. 17, 2021
Int. Cl. A61M 16/14 (2006.01); A61K 9/00 (2006.01); A61K 31/16 (2006.01); A61K 33/00 (2006.01); A61K 47/02 (2006.01); A61K 47/18 (2017.01); A61K 47/20 (2006.01); A61K 47/22 (2006.01); A61K 47/24 (2006.01); A61M 16/06 (2006.01); C01B 21/24 (2006.01)
CPC A61M 16/14 (2013.01) [A61K 9/0073 (2013.01); A61K 31/16 (2013.01); A61K 33/00 (2013.01); A61K 47/02 (2013.01); A61K 47/183 (2013.01); A61K 47/20 (2013.01); A61K 47/22 (2013.01); A61K 47/24 (2013.01); A61M 16/06 (2013.01); C01B 21/24 (2013.01); A61M 2202/0275 (2013.01); A61M 2202/062 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A moisture or hydrating liquid activatable solid formulation for nitric oxide (NO) generation, comprising:
a nitrite source that is to generate NO when exposed to an effective amount of moisture or a hydrating liquid, the nitrite source being selected from the group consisting of ammonium nitrites, alkyl nitrites, dicyclohexylamine nitrite, phosphazine nitrites, and nitrite salts;
a copper (I) or copper (II) catalyst;
an NO generation accelerant present in an amount of from about 27 wt % to about 50 wt % based on a total weight of the moisture or hydrating liquid activatable solid formulation; and
a pH buffer present in a total amount of from about 1 wt % to about 32 wt % based on the total weight of the moisture or hydrating liquid activatable solid formulation, the pH buffer being a monobasic or a dibasic phosphate,
wherein a pH of the moisture or hydrating liquid activatable solid formulation is from greater than 4 to about 9.0.