US 11,986,582 B2
Medicament preparation and treatment devices, methods, and systems
Goetz Friederichs, Beverly, MA (US); William K. Weigel, Portland, ME (US); Dennis M. Treu, Castle Rock, CO (US); Jeffrey H. Burbank, Manchester, MA (US); James M. Brugger, Newburyport, MA (US); Keith David J. Wheeler, Tyngsboro, MA (US); and Scott W. Newell, Ipswich, MA (US)
Assigned to NxStage Medical, Inc., Lawrence, MA (US)
Filed by NxStage Medical, Inc., Lawrence, MA (US)
Filed on Oct. 26, 2021, as Appl. No. 17/511,348.
Application 17/511,348 is a continuation of application No. 16/575,482, filed on Sep. 19, 2019, granted, now 11,167,069.
Application 16/575,482 is a continuation of application No. 15/514,230, granted, now 10,478,544, previously published as PCT/US2015/052385, filed on Sep. 25, 2015.
Claims priority of provisional application 62/055,022, filed on Sep. 25, 2014.
Prior Publication US 2022/0047790 A1, Feb. 17, 2022
Int. Cl. A61M 1/16 (2006.01); A61K 31/191 (2006.01); A61M 1/14 (2006.01); A61M 1/36 (2006.01); B01F 21/20 (2022.01); C02F 9/00 (2023.01); F15B 1/04 (2006.01); C02F 1/20 (2023.01); C02F 1/28 (2023.01); C02F 1/42 (2023.01); C02F 1/44 (2023.01); C02F 103/02 (2006.01); C02F 103/04 (2006.01)
CPC A61M 1/1666 (2014.02) [A61K 31/191 (2013.01); A61M 1/1524 (2022.05); A61M 1/154 (2022.05); A61M 1/155 (2022.05); A61M 1/1561 (2022.05); A61M 1/1562 (2022.05); A61M 1/1565 (2022.05); A61M 1/1658 (2013.01); A61M 1/166 (2014.02); A61M 1/362227 (2022.05); A61M 1/36224 (2022.05); A61M 1/36225 (2022.05); A61M 1/362261 (2022.05); A61M 1/362262 (2022.05); A61M 1/362265 (2022.05); B01F 21/20 (2022.01); C02F 9/00 (2013.01); F15B 1/04 (2013.01); A61M 1/1563 (2022.05); A61M 1/362263 (2022.05); A61M 2205/3317 (2013.01); A61M 2205/3368 (2013.01); A61M 2205/502 (2013.01); A61M 2205/6054 (2013.01); A61M 2205/6072 (2013.01); C02F 1/20 (2013.01); C02F 1/283 (2013.01); C02F 1/42 (2013.01); C02F 2001/425 (2013.01); C02F 2001/427 (2013.01); C02F 1/44 (2013.01); C02F 2103/026 (2013.01); C02F 2103/04 (2013.01); C02F 2209/05 (2013.01); C02F 2209/445 (2013.01); F15B 2201/315 (2013.01); Y02A 50/30 (2018.01)] 20 Claims
OG exemplary drawing
 
1. A medicament preparation system for preparing a medicament, comprising:
a water purification module with a tap water inlet and a purified water outlet;
a medicament proportioning module that is interoperable with a replaceable fluid circuit that includes
a purified water inlet that receives purified water from the purified water outlet of the water purification module,
a product medicament outlet configured to output the medicament,
a medicament supply channel fluidly connecting the purified water inlet to the product medicament outlet, and
a plurality of pumping tube segments, that include a first pumping tube segment fluidly connected between the purified water inlet and the medicament supply channel and a second pumping tube segment fluidly connected between a first concentrate container and the medicament supply channel;
at least the first concentrate container connected by at least a portion of the replaceable fluid circuit to the product medicament outlet;
a first concentration measurement sensor station positioned in a flow path of the replaceable fluid circuit; and
a controller programmed to calculate iteratively a concentration of a first concentrate from the first concentrate container and the purified water from a signal generated by the first concentration measurement sensor station and to regulate one or both of a first pumping actuator engaged with the first pumping tube segment and a second pumping actuator engaged with the second pumping tube segment, responsively to the concentration of the first concentrate and the purified water, wherein
the controller is programmed to calculate iteratively a concentration of a second concentrate and the first concentrate and the purified water from a signal generated by a second concentration measurement sensor station and to regulate at least two of the first and second pumping actuators and a third pumping actuator engaged with a third pumping tube segment, that connects a second concentrate container to the medicament supply channel, responsively to the concentration of the first and second concentrates and the purified water.