US 11,986,581 B2
Method, facility and tank for the manufacture of a liquid acid concentrate used for hemodialysis machines
Thierry Eyrard, Lyons (FR); Philippe Laffay, Sainte-foy-les-Lyon (FR); and Benoit Luaire, Sourcieux-les-Mines (FR)
Assigned to FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH, Bad Homburg (DE)
Appl. No. 16/461,822
Filed by FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH, Bad Homburg (DE)
PCT Filed Nov. 16, 2017, PCT No. PCT/EP2017/079446
§ 371(c)(1), (2) Date May 17, 2019,
PCT Pub. No. WO2018/091585, PCT Pub. Date May 24, 2018.
Claims priority of application No. 1661283 (FR), filed on Nov. 21, 2016.
Prior Publication US 2019/0358386 A1, Nov. 28, 2019
Int. Cl. A61M 1/16 (2006.01); A61K 9/08 (2006.01); A61K 33/14 (2006.01); B01F 21/00 (2022.01); B01F 21/10 (2022.01); B01F 23/53 (2022.01); B01F 25/50 (2022.01); B01F 25/52 (2022.01); B01F 35/21 (2022.01); A61K 9/00 (2006.01); B01F 23/50 (2022.01)
CPC A61M 1/1656 (2013.01) [A61K 9/08 (2013.01); A61K 33/14 (2013.01); B01F 21/02 (2022.01); B01F 21/10 (2022.01); B01F 23/53 (2022.01); B01F 25/50 (2022.01); B01F 25/52 (2022.01); B01F 35/2117 (2022.01); B01F 35/2133 (2022.01); B01F 35/2134 (2022.01); A61K 9/0019 (2013.01); A61M 2205/3393 (2013.01); B01F 21/30 (2022.01); B01F 23/511 (2022.01); B01F 23/56 (2022.01)] 11 Claims
OG exemplary drawing
 
1. A facility for manufacturing a predetermined quantity of a batch of liquid acid concentrate for hemodialysis machines wherein the facility comprises:
a mixing tank;
a water source connected to the mixing tank via a water introduction line;
an electrolyte tank containing a mixture of the electrolytes potassium and/or calcium and/or magnesium in exact quantities needed to manufacture the batch of liquid acid concentrate, wherein said mixture optionally further contains at most one part of acid and/or at most one part of sodium chloride needed for the manufacture of the batch of liquid acid concentrate, wherein the electrolyte tank is equipped with a single bag line allowing both the transfer of a solution from the mixing tank into the electrolyte tank, as well as the transfer of the solution from the electrolyte tank into the mixing tank, wherein the single bag line is equipped with a connector for connection to a withdrawal line used to transfer the solution from the mixing tank into the electrolyte tank and to a return line used to transfer the solution from the electrolyte tank into the mixing tank;
the withdrawal line leads from the mixing tank to the electrolyte tank to transfer part of the solution from the mixing tank into the electrolyte tank and the return line leads from the electrolyte tank to the mixing tank for transferring the solution contained in the electrolyte tank into the mixing tank, wherein the withdrawal line and the return line are one and the same line, two different lines, or a combination of the same and different lines;
a recirculation line;
at least one pump to convey solution in the withdrawal line, the return line, and the recirculation line;
an acid source connected to the mixing tank and configured to introduce the acid at a quantity needed for the manufacture of the batch into the mixing tank, taking into account the acid that is optionally already present in the electrolyte tank; and
a sodium chloride source connected to the mixing tank, the sodium chloride source configured to introduce a solid sodium chloride at a quantity needed for the manufacture of the batch into the mixing tank, taking into account the sodium chloride that is optionally already present in the electrolyte tank.