US 11,986,572 B2
Device for the non-invasive induction of dynamic deformation of body tissue to differentiate tissue cells
Nicolas Perren, Dessau (DE); and Stephan Perren, Davos (CH)
Assigned to Nicolas Perren, Dessau (DE)
Appl. No. 16/754,434
Filed by Nicolas Perren, Dessau (DE); and Alice Perren, Davos (CH)
PCT Filed Oct. 17, 2017, PCT No. PCT/CH2017/000093
§ 371(c)(1), (2) Date Apr. 8, 2020,
PCT Pub. No. WO2019/075584, PCT Pub. Date Apr. 5, 2019.
Prior Publication US 2021/0196857 A1, Jul. 1, 2021
Int. Cl. A61L 27/36 (2006.01); A61L 27/04 (2006.01); A61L 27/06 (2006.01); A61L 27/08 (2006.01); A61L 27/38 (2006.01)
CPC A61L 27/365 (2013.01) [A61L 27/042 (2013.01); A61L 27/045 (2013.01); A61L 27/06 (2013.01); A61L 27/08 (2013.01); A61L 27/3608 (2013.01); A61L 27/3691 (2013.01); A61L 27/3821 (2013.01); A61L 27/3847 (2013.01); A61L 2430/02 (2013.01)] 14 Claims
 
1. A device for noninvasive induction of dynamic deformation of body tissue to differentiate tissue cells, which comprises the following components:
(i) a suspension of particles suspended in a solution; and
(ii) an external actuator;
wherein:
a) the particles are metallic, magnetic, magnetizable, electrically chargeable, or thermally reactive;
b) the average diameter of the particles is greater than 5 μm and less than 5 mm;
c) the external actuator comprises a vibration source or a heat source or is configured to emit electromagnetic waves or to generate an electrical field to stimulate the suspended particles vibrationally, thermally, magnetically or electrically;
d) the solution is a body-compatible liquid that contains bone-forming substances and/or tissue components and/or stem cells;
e) the suspended particles are structurally configured so as to be capable of being repeatedly stimulated by the external actuator, after injection into the body tissue, to move and thereby noninvasively induce dynamic deformation of the body tissue to differentiate the tissue cells; and
f) wherein the particles comprise one or more substances selected from the group consisting of platinum, titanium, steel, carbon steel, martensitic steels, crystalline and amorphous alloys based on iron, nickel, cobalt, soft ferrites, hard ferrites, cobalt samarium, neodymium iron-boron, AlNiCo and memory alloys.