CPC A61L 15/225 (2013.01) [A61L 15/26 (2013.01); A61L 15/28 (2013.01); A61L 15/425 (2013.01); A61L 15/44 (2013.01); A61L 15/64 (2013.01); A61L 31/042 (2013.01); A61L 31/06 (2013.01); A61L 31/129 (2013.01); A61L 31/146 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); C08L 67/04 (2013.01); A61L 2300/252 (2013.01); A61L 2300/404 (2013.01); A61L 2300/414 (2013.01); A61L 2300/45 (2013.01); A61L 2300/604 (2013.01); A61L 2300/624 (2013.01)] | 15 Claims |
1. A wound dressing comprising:
a plurality of meshes formed from a plurality of biodegradable polymer fibers;
wherein the biodegradable polymer fibers comprise a first active agent;
wherein the plurality of meshes further comprise a plurality of biodegradable polymer particles;
wherein the biodegradable polymer particles comprise a second active agent;
wherein an in vivo or in vitro release profile of the first active agent differs from an in vivo or in vitro release profile of the second active agent;
wherein the plurality of meshes are arranged in a stack,
wherein the stack has a top surface and a bottom surface, wherein the bottom surface is defined by a mesh placed on a wound and the top surface is defined by a mesh disposed farthermost from the wound, wherein the stack having a property gradient in a z-direction of the stack such that the property increases from the bottom surface to the top surface or such that the property decreases from the bottom surface to the top surface of the stack, wherein the z-direction is defined in a stacking direction; and
wherein the plurality of meshes is at least three meshes, and wherein the property is defined by a mesh porosity or a mesh perforation.
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