US 11,986,561 B2
Wound dressings and applications thereof
Jian Yang, State College, PA (US); Kytai T. Nguyen, Grand Prairie, TX (US); and Zhiwei Xie, State College, PA (US)
Assigned to THE PENN STATE RESEARCH FOUNDATION, University Park, PA (US); and BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed by THE PENN STATE RESEARCH FOUNDATION, University Park, PA (US); and BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed on Oct. 12, 2021, as Appl. No. 17/499,221.
Application 17/499,221 is a continuation of application No. 14/891,862, granted, now 11,173,227, previously published as PCT/US2014/038942, filed on May 21, 2014.
Claims priority of provisional application 61/826,328, filed on May 22, 2013.
Prior Publication US 2022/0023484 A1, Jan. 27, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 15/22 (2006.01); A61L 15/26 (2006.01); A61L 15/28 (2006.01); A61L 15/42 (2006.01); A61L 15/44 (2006.01); A61L 15/64 (2006.01); A61L 31/04 (2006.01); A61L 31/06 (2006.01); A61L 31/12 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); C08L 67/04 (2006.01)
CPC A61L 15/225 (2013.01) [A61L 15/26 (2013.01); A61L 15/28 (2013.01); A61L 15/425 (2013.01); A61L 15/44 (2013.01); A61L 15/64 (2013.01); A61L 31/042 (2013.01); A61L 31/06 (2013.01); A61L 31/129 (2013.01); A61L 31/146 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); C08L 67/04 (2013.01); A61L 2300/252 (2013.01); A61L 2300/404 (2013.01); A61L 2300/414 (2013.01); A61L 2300/45 (2013.01); A61L 2300/604 (2013.01); A61L 2300/624 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A wound dressing comprising:
a plurality of meshes formed from a plurality of biodegradable polymer fibers;
wherein the biodegradable polymer fibers comprise a first active agent;
wherein the plurality of meshes further comprise a plurality of biodegradable polymer particles;
wherein the biodegradable polymer particles comprise a second active agent;
wherein an in vivo or in vitro release profile of the first active agent differs from an in vivo or in vitro release profile of the second active agent;
wherein the plurality of meshes are arranged in a stack,
wherein the stack has a top surface and a bottom surface, wherein the bottom surface is defined by a mesh placed on a wound and the top surface is defined by a mesh disposed farthermost from the wound, wherein the stack having a property gradient in a z-direction of the stack such that the property increases from the bottom surface to the top surface or such that the property decreases from the bottom surface to the top surface of the stack, wherein the z-direction is defined in a stacking direction; and
wherein the plurality of meshes is at least three meshes, and wherein the property is defined by a mesh porosity or a mesh perforation.