US 11,986,559 B2
Method for coating pharmaceutical substrates
Pekka Hoppu, Kitee (FI); Tommi Kaariainen, Mikkeli (FI); Marja-Leena Kaariainen, Mikkeli (FI); and Aimo Turunen, Kitee (FI)
Assigned to Applied Materials, Inc., Santa Clara, CA (US)
Filed by Applied Materials, Inc., Santa Clara, CA (US)
Filed on Nov. 1, 2022, as Appl. No. 17/978,700.
Application 17/978,700 is a division of application No. 16/806,625, filed on Mar. 2, 2020, granted, now 11,672,764.
Application 15/275,900 is a division of application No. 14/428,530, abandoned, previously published as PCT/FI2013/050896, filed on Sep. 17, 2013.
Application 16/806,625 is a continuation of application No. 15/275,900, filed on Sep. 26, 2016, granted, now 10,603,284, issued on Mar. 31, 2020.
Claims priority of application No. 20125962 (FI), filed on Sep. 18, 2012.
Prior Publication US 2023/0059964 A1, Feb. 23, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/20 (2006.01); A61K 9/50 (2006.01); A61K 31/167 (2006.01); C23C 16/00 (2006.01); C23C 16/40 (2006.01); C23C 16/455 (2006.01)
CPC A61K 9/2095 (2013.01) [A61K 9/2009 (2013.01); A61K 9/2018 (2013.01); A61K 9/2077 (2013.01); A61K 9/2081 (2013.01); A61K 9/501 (2013.01); A61K 9/5015 (2013.01); A61K 31/167 (2013.01); C23C 16/403 (2013.01); C23C 16/405 (2013.01); C23C 16/45525 (2013.01); C23C 16/45555 (2013.01)] 31 Claims
 
1. A method for coating individual nanoparticles or microparticles consisting of an active pharmaceutical substance, the method comprising:
providing a plurality of freely flowing individual nanoparticles or microparticles consisting of an active pharmaceutical substance; and
subjecting the plurality of freely flowing individual nanoparticles or microparticles to alternating surface reactions of at least a first and a second gaseous precursor by atomic layer deposition thereby fully encapsulating the plurality of freely flowing individual nanoparticles or microparticles with a coating layer, wherein the active pharmaceutical substance is an organic compound.