US 11,986,533 B2
Macromonomers and bottle brush polymers for delivery of biological agents
Theresa Reineke, Vadnais Heights, MN (US); Frank S. Bates, Saint Louis Park, MN (US); and Monica Ohnsorg, Chanhassen, MN (US)
Assigned to Regents of the University of Minnesota, Minneapolis, MN (US)
Filed by Regents of the University of Minnesota, Minneapolis, MN (US)
Filed on Jan. 21, 2022, as Appl. No. 17/648,642.
Claims priority of provisional application 63/199,785, filed on Jan. 25, 2021.
Prior Publication US 2022/0339288 A1, Oct. 27, 2022
Int. Cl. A61K 47/59 (2017.01); C08G 81/02 (2006.01)
CPC A61K 47/59 (2017.08) [C08G 81/024 (2013.01)] 20 Claims
 
1. A composition, comprising:
a macromolecular polyacrylamide copolymer excipient with an α-end comprising a ROMP-active norbornene end-group and a co-end comprising a terminal monomer with an end group chosen from:
a hydrogen atom (H); or
a functionalized acrylate with functionality chosen from alkyl, hydroxyl (OH), methyl-polyethylene glycol ((PEG)-CH3), hydroxy-PEG (PEG-OH), carboxylic acid (COOH), and combinations thereof; and
a biological compound non-covalently bound with the macromolecular excipient, wherein the biological compound is chosen from active pharmaceutical ingredients, proteins, polynucleotides, and mixtures and combinations thereof.