US 11,986,522 B2
Immunotherapeutic composition and uses thereof
Robyn Elizabeth O'Hehir, Parkville (AU); Sara Rachel Prickett, Elwood (AU); and Jennifer May Rolland, Toorak (AU)
Assigned to ARA VAX PTY LTD, Melbourne (AU)
Filed by ARAVAX PTY LTD, Melbourne (AU)
Filed on Feb. 15, 2022, as Appl. No. 17/672,571.
Application 17/672,571 is a division of application No. 15/024,666, granted, now 11,266,737, previously published as PCT/AU2014/050249, filed on Sep. 25, 2014.
Claims priority of application No. 2013903686 (AU), filed on Sep. 25, 2013.
Prior Publication US 2022/0280637 A1, Sep. 8, 2022
Int. Cl. A61K 39/35 (2006.01); A61K 31/7088 (2006.01); A61K 38/08 (2019.01); A61K 38/10 (2006.01); A61K 39/00 (2006.01); A61P 37/00 (2006.01); A61P 37/08 (2006.01)
CPC A61K 39/35 (2013.01) [A61K 31/7088 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61P 37/00 (2018.01); A61P 37/08 (2018.01); A61K 2039/54 (2013.01); A61K 2039/577 (2013.01)] 21 Claims
 
1. A composition comprising a mixture of nucleic acid molecules,
wherein at least four or more of the nucleic acid molecules in the mixture are selected from
(i) a nucleic acid molecule encoding or complementary to a sequence encoding
 
 (SEQ ID NO: 11)
 
 FQNLQNHRIVQIEAKPNTLV;
(ii) a nucleic acid molecule encoding or complementary to a sequence encoding
 
 (SEQ ID NO: 12)
 
 STRSSENNEGVIVKVSKE;
(iii) a nucleic acid molecule encoding or complementary to a sequence encoding
 
 
 (SEQ ID NO: 4)
 
 
 EVKPDKKNPQLQ;
(iv) a nucleic acid molecule encoding or complementary to a sequence encoding
 
 (SEQ ID NO: 13)
 
 VEIKEGALMLPHFNSKA;
and
(v) a nucleic acid molecule encoding or complementary to a sequence encoding
 
 (SEQ ID NO: 14)
 
 VFIMPAAHPVAINASS,
and
wherein at least two or more of the nucleic acid molecules in the mixture are selected from
(vi) a nucleic acid molecule encoding or complementary to a sequence encoding
 
 
 (SEQ ID NO: 30)
 
 
 ANLRPSEQHLM;
(vii) a nucleic acid molecule encoding or complementary to a sequence encoding
 
 
 (SEQ ID NO: 31)
 
 
 EFENNQRSMSEALQ;
and
(viii) a nucleic acid molecule encoding or complementary to a sequence encoding
 
 
 (SEQ ID NO: 107)
 
 
 RELRNLPQQSGLRA.