	US 11,986,518 B2
	Immunogenic compositions
Christiane Gerke, Siena (IT); Laura Bartle Martin, Siena (IT); and Allan James Saul, Siena (IT)
Assigned to GLAXOSMITHKLINE BIOLOGICALS SA, Rixensart (BE)
Filed by GLAXOSMITHKLINE BIOLOGICALS SA, Rixensart (BE)
Filed on Aug. 5, 2020, as Appl. No. 16/985,979.
Application 16/985,979 is a division of application No. 15/736,691, abandoned, previously published as PCT/EP2016/063776, filed on Jun. 15, 2016.
Claims priority of application No. 15020097 (EP), filed on Jun. 16, 2015.
Prior Publication US 2020/0384096 A1, Dec. 10, 2020
Int. Cl. A61K 39/112 (2006.01); A61K 39/00 (2006.01)

CPC A61K 39/0283 (2013.01) [A61K 2039/55505 (2013.01); A61K 2039/55572 (2013.01); A61K 2039/70 (2013.01); Y02A 50/30 (2018.01)]

12 Claims

1. An immunogenic composition comprising:

(a) purified Shigella sonnei Generalized Modules for Membrane Antigens (GMMA) purified from at least one strain selected from the group consisting of

(i) Shigella sonnei ΔtolR, ΔhtrB, ΔvirG::nadAB,

(ii) Shigella sonnei ΔtolR, ΔmsbB1, ΔvirG::nadAB,

(iii) Shigella sonnei ΔtolR, ΔmsbB2, ΔvirG::nadAB, and

(iv) Shigella sonnei ΔtolR, ΔmsbB1 ΔmsbB2, ΔvirG::nadAB,

(b) purified Shigella flexneri GMMA purified from at least one strain selected from the group consisting of

(i) Shigella flexneri 2a ΔtolR, ΔmsbB,

(ii) Shigella flexneri 2a ΔtolR, ΔhtrB,

(iii) Shigella flexneri 3a ΔtolR, ΔmsbB,

(iv) Shigella flexneri 3a ΔtolR, ΔhtrB,

(v) Shigella flexneri 3a ΔtolR, ΔmsbB, and

(vi) Shigella flexneri 3a ΔtolR, ΔhtrB, and