US 11,986,502 B2
Bacteriophage compositions and kits and related methods
Laura Bridgewater, North Provo, UT (US); and Gongze Zhao, Highland, UT (US)
Assigned to Optium, LLC, Provo, UT (US)
Appl. No. 17/058,020
Filed by BRIGHAM YOUNG UNIVERSITY, Provo, UT (US)
PCT Filed May 23, 2019, PCT No. PCT/US2019/033844
§ 371(c)(1), (2) Date Nov. 23, 2020,
PCT Pub. No. WO2019/226950, PCT Pub. Date Nov. 28, 2019.
Claims priority of provisional application 62/815,844, filed on Mar. 8, 2019.
Claims priority of provisional application 62/675,652, filed on May 23, 2018.
Prior Publication US 2021/0196769 A1, Jul. 1, 2021
Int. Cl. A61K 35/76 (2015.01); A61K 35/745 (2015.01); A61K 35/747 (2015.01); A61K 35/00 (2006.01)
CPC A61K 35/76 (2013.01) [A61K 35/745 (2013.01); A61K 35/747 (2013.01); A61K 2035/115 (2013.01)] 20 Claims
 
1. A composition, comprising:
a pharmaceutically-acceptable carrier; and
greater than or equal to 1×104 PFU of each of a plurality of bacteriophages, the plurality of bacteriophages comprising:
a first bacteriophage having a genome with greater than or equal to 80% sequence identity to a first one of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:5, or SEQ ID NO:6;
a second bacteriophage having a genome with greater than or equal to 80% sequence identity to a second one of SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:5, or SEQ ID NO:6;
a third bacteriophage having a genome with greater than or equal to 80% sequence identity to a first one of SEQ ID NO:1, SEQ ID NO:4, SEQ ID NO:10, or SEQ ID NO:14;
a fourth bacteriophage having a genome with greater than or equal to 80% sequence identity to a second one of SEQ ID NO:1, SEQ ID NO:4, SEQ ID NO:10, or SEQ ID NO:14;
a fifth bacteriophage having a genome with greater than or equal to 80% sequence identity to a first one of SEQ ID NO:7, SEQ ID NO:8, or SEQ ID NO:9;
a sixth bacteriophage having a genome with greater than or equal to 80% sequence identity to a second one of SEQ ID NO:7, SEQ ID NO:8, or SEQ ID NO:9;
a seventh bacteriophage having a genome with greater than or equal to 80% sequence identity to a first one of SEQ ID NO:12, nucleic acid bases 1-59,985 of SEQ ID NO:13, or SEQ ID NO:15; and
an eighth bacteriophage having a genome with greater than or equal to 80% sequence identity to a second one of SEQ ID NO:12, nucleic acid bases 1-59,985 of SEQ ID NO:13, or SEQ ID NO:15.