US 11,986,499 B2
Treatment and prevention of neuropathology associated with neurodegenerative diseases
Keith Rubin, Fort Lauderdale, FL (US); Steven Glazer, Weston, CT (US); Marina Lynch, Dublin (IE); and Kingston Mills, Dublin (IE)
Assigned to ILiAD Biotechnologies, LLC, Weston, FL (US)
Filed by ILiAD Biotechnologies, LLC, Weston, FL (US)
Filed on Nov. 16, 2021, as Appl. No. 17/455,173.
Claims priority of provisional application 63/114,909, filed on Nov. 17, 2020.
Prior Publication US 2022/0152123 A1, May 19, 2022
Int. Cl. A61K 35/74 (2015.01); A61P 25/28 (2006.01)
CPC A61K 35/74 (2013.01) [A61P 25/28 (2018.01)] 10 Claims
 
1. A method for preventing or reducing β-amyloid plaque in the brain of a subject having or at risk for developing Alzheimer's disease, the method comprising the step of administering to the subject a composition comprising a live, attenuated Bordetella pertussis strain which is able to colonize the subject and induce a protective response in the subject that reduces the amount of β-amyloid plaque that would have formed or would have been present in the brain of the subject if the subject were not administered the composition.