US 11,986,491 B2
Pharmaceutical compositions comprising iodine and steroid and uses thereof for sinus diseases
Bo Liang, Plainsboro, NJ (US); Belachew Tessema, Famington, CT (US); Joseph A. Capriotti, Las Palmas (ES); Michael C. Samson, New York, NY (US); and Wei Song, Jiangsu (CN)
Assigned to IVIEW THERAPEUTICS, INC., Cranbury, NJ (US)
Appl. No. 14/127,846
Filed by Bo Liang, Plainsboro, NJ (US); Belachew Tessema, Famington, CT (US); Joseph A. Capriotti, Las Palmas (ES); Michael C. Samson, New York, NY (US); and Wei Song, Jiangsu (CN)
PCT Filed Jun. 22, 2011, PCT No. PCT/US2011/041470
§ 371(c)(1), (2), (4) Date Mar. 14, 2014,
PCT Pub. No. WO2012/177251, PCT Pub. Date Dec. 27, 2012.
Prior Publication US 2014/0219949 A1, Aug. 7, 2014
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/79 (2006.01); A61K 9/00 (2006.01); A61K 31/38 (2006.01); A61K 31/56 (2006.01); A61K 31/573 (2006.01); A61K 31/58 (2006.01); A61P 11/00 (2006.01)
CPC A61K 31/79 (2013.01) [A61K 9/0043 (2013.01); A61K 31/38 (2013.01); A61K 31/56 (2013.01); A61K 31/573 (2013.01); A61K 31/58 (2013.01)] 7 Claims
 
1. A pharmaceutical composition for treating a sinus inflammation or infection of a patient in need thereof, consisting of:
water as a carrier;
an iodine-containing compound, wherein the iodine-containing compound is povidone-iodine, and the concentration of povidone-iodine in a fully constituted aqueous solution ranges from about 0.01% to about 15% by weight/weight or weight/volume percentage based on the total weight or volume of the pharmaceutical composition;
a steroid, wherein the steroid is budesonide or a salt or ester thereof, and at least 91% of steroid remains in the pharmaceutical composition after the pharmaceutical composition is stored at a temperature in the range of 5-40° C. for a month; and
optionally one or more agents selected from the group consisting of microcrystalline cellulose, carboxymethyl cellulose sodium, polysorbate 80, disodium edetate, sodium chloride, hydrochloric acid, and sodium hydroxide.