US 11,986,480 B2
Heterocyclic compound
Hirokazu Arimoto, Sendai (JP); Kaori Itto, Sendai (JP); Daiki Takahashi, Sendai (JP); Nobuo Cho, Fujisawa (JP); Hiroshi Nara, Fujisawa (JP); Kenichiro Shimokawa, Fijisawa (JP); Taiichi Ohra, Fujisawa (JP); Shigekazu Sasaki, Fujisawa (JP); and Naoki Ishii, Fujisawa (JP)
Assigned to TOHOKU UNIVERSITY, Miyagi (JP)
Appl. No. 16/482,994
Filed by TOHOKU UNIVERSITY, Sendai (JP)
PCT Filed Feb. 2, 2018, PCT No. PCT/JP2018/003576
§ 371(c)(1), (2) Date Oct. 28, 2019,
PCT Pub. No. WO2018/143403, PCT Pub. Date Aug. 9, 2018.
Claims priority of application No. 2017-019127 (JP), filed on Feb. 3, 2017.
Prior Publication US 2020/0163970 A1, May 28, 2020
Int. Cl. C07D 495/04 (2006.01); A61K 31/513 (2006.01); A61K 31/522 (2006.01); A61K 31/551 (2006.01)
CPC A61K 31/522 (2013.01) [A61K 31/513 (2013.01); A61K 31/551 (2013.01); C07D 495/04 (2013.01)] 13 Claims
 
1. A compound or a salt thereof, the compound being represented by the following formula (I):

OG Complex Work Unit Chemistry
wherein
R1 represents a halogenated C1-C12 alkoxy group,

OG Complex Work Unit Chemistry
La represents a bond or a chain linker having 1 to 10 atoms in a backbone,
Lb represents
i) a bond,
ii) a chain linker having 1 to 13 atoms in a backbone, or
iii) formula (II)

OG Complex Work Unit Chemistry
wherein L1 represents a bond or a chain linker having 1 to 10 atoms in a backbone,
X1 represents an optionally substituted divalent cyclic group, and
L2 represents a bond or a chain linker having 1 or 2 atoms in a backbone, and
R2 represents a group selected from the following formulas:

OG Complex Work Unit Chemistry
wherein
RA1, RA2, RA3, RA4, RA5, and RA6 each independently represent a hydrogen atom or a substituent,
RB1, RB2, and RB3 each independently represent an optionally substituted hydrocarbon ring group, an optionally substituted unsaturated heterocyclic group, or —X2—R3,
wherein X2 represents an optionally substituted methylene group, and R3 represents an optionally substituted cyclic group.