US 11,986,476 B1
(6-methyl-4-substitutedphenyl-2-oxo/thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)(piperidin-1-yl)methanones as antitubercular agents
Katharigatta N. Venugopala, Al-Ahsa (SA); Keshab M. Bairagi, Nagpur (IN); Pran Kishore Deb, Ranchi (IN); Melendran Pillay, Durban (CA); Mohamed A. Morsy, Al-Ahsa (SA); Susanta K. Nayak, Nagpur (IN); Sandeep Chandrashekharappa, Lucknow (IN); and Osama I. Alwassil, Riyadh (SA)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on Sep. 13, 2023, as Appl. No. 18/367,635.
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/506 (2006.01); A61K 31/505 (2006.01); A61P 31/06 (2006.01)
CPC A61K 31/506 (2013.01) [A61K 31/505 (2013.01); A61P 31/06 (2018.01)] 4 Claims
 
1. A method of treating tuberculosis in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a compound having the formula I:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
R1 is trifluoromethyl;
R2 is selected from the group consisting of piperidine and pyrrolidine;
X is S and
n is 1 or 2.