CPC A61K 31/22 (2013.01) [A61K 9/14 (2013.01); A61K 9/1676 (2013.01); A61K 9/5015 (2013.01); A61K 9/5026 (2013.01); A61K 9/5042 (2013.01); A61K 9/5078 (2013.01); A61K 9/5084 (2013.01); A61K 31/19 (2013.01)] | 26 Claims |
1. A method of treating narcolepsy-related cataplexy or excessive daytime sleepiness in a human patient in need thereof, the method comprising:
initiating a dosage of a gamma-hydroxybutyrate (GHB) formulation equivalent to 4.5 g of sodium oxybate once per night orally, wherein the GHB formulation comprises an immediate-release (IR) portion and a modified-release (MR) portion, and wherein the GHB of the IR portion is the same as or different from the GHB of the MR portion;
up-titrating the once per night dosage in an amount equivalent to 1.5 g of sodium oxybate,
maintaining the up-titrated once per night dosage for at least a week before any further up-titrating; and
ceasing any further up-titrating upon effect.
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