CPC A61K 31/047 (2013.01) [A61K 31/05 (2013.01); A61K 31/09 (2013.01); A61K 31/12 (2013.01); A61K 31/122 (2013.01); A61K 31/192 (2013.01); A61K 31/196 (2013.01); A61K 31/351 (2013.01); A61K 31/353 (2013.01); A61K 31/404 (2013.01); A61K 31/416 (2013.01); A61K 31/5513 (2013.01); A61P 35/00 (2018.01); C07C 35/42 (2013.01); C07C 43/295 (2013.01); C07C 49/577 (2013.01); C07C 205/45 (2013.01); C07C 271/58 (2013.01); C07C 317/44 (2013.01); C07D 243/24 (2013.01); C07D 309/14 (2013.01); C07D 407/04 (2013.01); C07D 493/04 (2013.01)] | 16 Claims |
1. A method of inhibiting respiratory complex III in a cell, comprising:
contacting the cell with a compound having a structure selected from the group consisting of:
![]() ![]() wherein
each R1, R2, R3, R4, R5, and R6 is independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 alkylhydroxy, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C6-12 aryl, halogen, hydroxyl, oxide, —CN, —NH2, —NO2, and —C(O)—C1-6 alkyl, and —C(O)O−;
the subscripts m and n are each independently integers from 0 to 5;
the subscript p is an integer from 0 to 4; and
the subscripts q, u, and v are each independently integers from 0 to 2;
such that the compound binds to respiratory complex III, thereby inhibiting respiratory complex III.
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