US 11,986,380 B2
Bending-resistant nerve catheter and preparation method and application thereof
Meifeng Zhu, Tianjin (CN); Deling Kong, Tianjin (CN); Xianhao Dong, Tianjin (CN); and Guangzhou Song, Tianjin (CN)
Assigned to Neosheng (Tianjin) Biotechnology Co., Ltd, Tainjin (CN); and Nankai University, Tainjin (CN)
Filed by Neosheng (Tianjin) Biotechnology Co., Ltd, Tianjin (CN); and Nankai University, Tianjin (CN)
Filed on May 1, 2023, as Appl. No. 18/310,306.
Claims priority of application No. 202210510177.0 (CN), filed on May 11, 2022.
Prior Publication US 2023/0363881 A1, Nov. 16, 2023
Int. Cl. A61F 2/02 (2006.01); A61F 2/00 (2006.01); A61F 2/04 (2013.01); D01D 5/00 (2006.01); D01D 5/06 (2006.01); D01D 5/08 (2006.01)
CPC A61F 2/0077 (2013.01) [A61F 2/04 (2013.01); D01D 5/0007 (2013.01); D01D 5/06 (2013.01); D01D 5/08 (2013.01); A61F 2002/0086 (2013.01); D10B 2201/00 (2013.01); D10B 2331/10 (2013.01); D10B 2401/062 (2013.01); D10B 2401/12 (2013.01); D10B 2509/00 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A bending-resistant nerve catheter, comprising an inner layer, a middle layer and an outer layer, wherein the inner layer, the middle layer and the outer layer are made of raw materials of biodegradable polymers;
the inner layer is a smooth surface inner layer, an oriented microchannel inner layer, or a fibrous inner layer capable of guiding directional migration of cells;
the middle layer is a fibrous middle layer with crossing angles, which is used to provide radial mechanical support; and
the outer layer is a fibrous outer layer distributed randomly;
the smooth surface inner layer has a thickness of 1-100 micrometers, the oriented microchannel inner layer has a thickness of 1-200 micrometers, or the fibrous inner layer has a fiber diameter of 0.1-200 micrometers and a thickness of 0.1-200 micrometers;
the fibrous middle layer of crossing angles is prepared by wet spinning or melt spinning;
the fibrous outer layer comprises fibers of a diameter of 0.01-200 micrometers, and the outer layer has a thickness of 10-400 micrometers; and
the bending-resistant nerve catheter forms no complete blockage after 180° bending.