CPC A61B 5/150961 (2013.01) [A61B 5/150755 (2013.01); B01L 3/502761 (2013.01); C12Q 1/689 (2013.01); A61B 5/150221 (2013.01); B01L 2200/16 (2013.01); B01L 2300/047 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0809 (2013.01); C12Q 1/6844 (2013.01); C12Q 1/6888 (2013.01)] | 21 Claims |
1. An integrated diagnostic cartridge, comprising:
a loading module;
a lysis module;
a purification module comprising a rotary valve comprising:
a. a stator comprising a stator face and a plurality of passages, each passage comprising a port at the stator face;
b. a rotor operably connected to the stator and comprising a rotational axis, a rotor valving face, and a flow channel having an inlet and an outlet at the rotor valving face;
c. a retention element biasing the stator and the rotor together at a rotor-stator interface to form a fluid tight seal;
d. a gasket interposed between the stator face and the rotor valving face having a pair of openings in fluidic communication with the flow channel inlet and the flow channel outlet;
a reaction module,
wherein the loading module is in fluidic communication with the lysis module and the purification module is in fluidic communication with the reaction module; and
the rotary valve further comprising a storage configuration and an operational configuration wherein in the operational configuration the gasket forms a fluid tight seal between the stator face and the rotor valving face.
|