US 11,986,299 B2
Diagnostic system
Sayeed Andeshmand, Dublin, CA (US); Thomas H. Cauley, III, Redwood City, CA (US); John Dixon, Moss Beach, CA (US); David Glade, San Ramon, CA (US); Hédia Maamar, San Jose, CA (US); Michael John McAdams, Los Gatos, CA (US); Dzam-Si Jesse Ng, Fremont, CA (US); and David Alexander Rolfe, San Francisco, CA (US)
Assigned to Talis Biomedical Corporation, Chicago, IL (US)
Filed by Talis Biomedical Corporation, Chicago, IL (US)
Filed on Nov. 2, 2020, as Appl. No. 17/087,479.
Application 17/087,479 is a division of application No. 16/655,007, filed on Oct. 16, 2019, granted, now 10,820,847.
Claims priority of provisional application 62/887,469, filed on Aug. 15, 2019.
Prior Publication US 2021/0251540 A1, Aug. 19, 2021
Int. Cl. A61B 5/15 (2006.01); B01L 3/00 (2006.01); C12Q 1/6844 (2018.01); C12Q 1/6888 (2018.01); C12Q 1/689 (2018.01)
CPC A61B 5/150961 (2013.01) [A61B 5/150755 (2013.01); B01L 3/502761 (2013.01); C12Q 1/689 (2013.01); A61B 5/150221 (2013.01); B01L 2200/16 (2013.01); B01L 2300/047 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/0809 (2013.01); C12Q 1/6844 (2013.01); C12Q 1/6888 (2013.01)] 21 Claims
OG exemplary drawing
 
1. An integrated diagnostic cartridge, comprising:
a loading module;
a lysis module;
a purification module comprising a rotary valve comprising:
a. a stator comprising a stator face and a plurality of passages, each passage comprising a port at the stator face;
b. a rotor operably connected to the stator and comprising a rotational axis, a rotor valving face, and a flow channel having an inlet and an outlet at the rotor valving face;
c. a retention element biasing the stator and the rotor together at a rotor-stator interface to form a fluid tight seal;
d. a gasket interposed between the stator face and the rotor valving face having a pair of openings in fluidic communication with the flow channel inlet and the flow channel outlet;
a reaction module,
wherein the loading module is in fluidic communication with the lysis module and the purification module is in fluidic communication with the reaction module; and
the rotary valve further comprising a storage configuration and an operational configuration wherein in the operational configuration the gasket forms a fluid tight seal between the stator face and the rotor valving face.