US 11,986,291 B2
Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis
Zhi Xu, St. Louis, MO (US)
Assigned to St. Louis Medical Devices, Inc., Sunnyvale, CA (US)
Filed by St. Louis Medical Devices, Inc., Sunnyvale, CA (US)
Filed on Jul. 29, 2021, as Appl. No. 17/388,489.
Application 13/610,140 is a division of application No. 12/425,535, filed on Apr. 17, 2009, granted, now 8,340,738, issued on Dec. 25, 2012.
Application 17/388,489 is a continuation of application No. 16/120,369, filed on Sep. 3, 2018, granted, now 11,076,781.
Application 16/120,369 is a continuation of application No. 15/408,052, filed on Jan. 17, 2017, granted, now 10,080,515.
Application 15/408,052 is a continuation of application No. 13/610,140, filed on Sep. 11, 2012, granted, now 9,579,049, issued on Feb. 28, 2017.
Claims priority of provisional application 61/089,152, filed on Aug. 15, 2008.
Claims priority of provisional application 61/055,303, filed on May 22, 2008.
Prior Publication US 2021/0353186 A1, Nov. 18, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); A61B 5/1455 (2006.01); G16Z 99/00 (2019.01)
CPC A61B 5/14532 (2013.01) [A61B 5/1455 (2013.01); A61B 5/6826 (2013.01); A61B 5/6838 (2013.01); A61B 5/7225 (2013.01); G16Z 99/00 (2019.02); A61B 2562/0238 (2013.01); A61B 2576/00 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A system for detecting glucose in a biological sample, comprising:
a processor programmed to calculate a change in a light absorption caused by blood in the biological sample and configured to receive an output photocurrent signal from at least one photocurrent signal generating light detector and calculate an attenuance attributable to blood in the biological sample present in a target area with a signal-to-noise ratio based on the received output photocurrent signal, and determine a blood glucose level associated with the biological sample present in the target area based on the calculated attenuance, wherein the processor is configured to calculate a peak-to-valley height of the change in light absorption due to blood in the biological sample in relationship to time, which is a function of a standard deviation of a logarithm of a time dependent output current divided by a proportionality constant, wherein the processor is programmed to reduce noise without increasing data acquisition time by using the standard deviation.