US 11,986,280 B2
Systems and methods for vascular diagnosis using blood flow magnitude and/or direction
Leo J. Grady, Darien, CT (US); and Charles A. Taylor, Atherton, CA (US)
Assigned to HeartFlow, Inc., Mountain View, CA (US)
Filed by HeartFlow, Inc., Redwood City, CA (US)
Filed on Mar. 22, 2021, as Appl. No. 17/208,832.
Application 17/208,832 is a continuation of application No. 14/691,105, filed on Apr. 20, 2015, granted, now 10,987,010.
Claims priority of provisional application 62/110,817, filed on Feb. 2, 2015.
Prior Publication US 2021/0228094 A1, Jul. 29, 2021
Int. Cl. A61B 5/026 (2006.01); A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 8/06 (2006.01); A61B 8/08 (2006.01); A61B 34/10 (2016.01); G16H 50/20 (2018.01); G16H 50/50 (2018.01)
CPC A61B 5/026 (2013.01) [A61B 5/02028 (2013.01); A61B 5/7246 (2013.01); A61B 5/7275 (2013.01); A61B 5/7278 (2013.01); A61B 5/74 (2013.01); A61B 8/06 (2013.01); A61B 8/0891 (2013.01); A61B 34/10 (2016.02); G16H 50/20 (2018.01); G16H 50/50 (2018.01); A61B 5/742 (2013.01); A61B 8/488 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A computer-implemented method of determining blood flow deviation in a patient's vasculature, the method comprising:
receiving a patient-specific anatomic model of at least a portion of a patient's vasculature;
modifying the patient-specific anatomic model to create a plurality of modified models, wherein each of the plurality of modified models includes a respective proposed treatment of a plurality of proposed treatments for a condition other than vascular steal syndrome;
receiving (1) a first reference blood flow magnitude indicating an amount of blood flow at a predetermined first location of a population-based reference vasculature, and (2) a second reference blood flow magnitude indicating an amount of blood flow at a predetermined second location of the population-based reference vasculature;
calculating a reference relative blood flow magnitude by comparing the first reference blood flow magnitude to the second reference blood flow magnitude;
for each modified model of the plurality of modified models:
(a) simulating, non-invasively, (1) a respective first patient-specific blood flow magnitude indicating a first amount of blood flow at a first location of the patient's vasculature corresponding to the predetermined first location of the population-based reference vasculature, and (2) a respective second patient-specific blood flow magnitude indicating a second amount of blood flow at a second location of the patient's vasculature corresponding to the predetermined first location of the population-based reference vasculature;
(b) determining a respective patient-specific relative blood flow magnitude by comparing the respective first patient-specific blood flow magnitude to the respective second patient-specific blood flow magnitude; and
(c) determining whether the respective proposed treatment induces vascular steal by determining a difference or ratio between the reference relative blood flow magnitude and the respective patient-specific relative blood flow magnitude; and
based on the determination of whether each of the respective proposed treatments induces vascular steal, providing a recommendation of at least one proposed treatment of the plurality of proposed treatments.