US 11,986,268 B2
System and method for the discrimination of tissues using a fast infrared cancer probe
James Coe, Worthington, OH (US); Heather Allen, Columbus, OH (US); Charles Hitchcock, Upper Arlington, OH (US); and Edward W. Martin, Delaware, OH (US)
Assigned to OHIO STATE INNOVATION FOUNDATION, Columbus, OH (US)
Filed by OHIO STATE INNOVATION FOUNDATION, Columbus, OH (US)
Filed on Apr. 26, 2023, as Appl. No. 18/139,722.
Application 18/139,722 is a continuation of application No. 16/085,210, granted, now 11,678,802, previously published as PCT/US2017/022670, filed on Mar. 16, 2017.
Claims priority of provisional application 62/309,116, filed on Mar. 16, 2016.
Prior Publication US 2023/0346223 A1, Nov. 2, 2023
Int. Cl. A61B 5/00 (2006.01); G01J 3/42 (2006.01); G01N 21/3563 (2014.01); G01N 21/552 (2014.01); A61B 17/00 (2006.01); A61B 90/00 (2016.01)
CPC A61B 5/0075 (2013.01) [A61B 5/444 (2013.01); G01J 3/42 (2013.01); G01N 21/3563 (2013.01); G01N 21/552 (2013.01); A61B 2017/00061 (2013.01); A61B 2090/373 (2016.02); A61B 2505/05 (2013.01); A61B 2576/00 (2013.01); G01J 2003/425 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A computer-assisted method of at least one of training a model or using a trained model for spectroscopically discriminating between cancerous and non-cancerous tissue of a specimen using infrared light, the method comprising:
illuminating the specimen with illuminating infrared light using a probe;
in response to the illuminating, training the model by analyzing response light from ground truth training samples of the specimen at specified wavelengths, wherein the wavelengths are specified using: (a) a specified metric comprising a ratio of absorbances of the illuminating infrared light in at least one of amide I, amide II, triglyceride, or glycogen spectral regions; and
(b) a Figure of Merit (FOM), based on the specified metric; and
applying the trained model to a further tissue specimen to discriminate between whether the further tissue specimen is cancerous or non-cancerous.