US 11,986,000 B2
Whey protein extracts and their use as sphingomyelin source
Jonathan O'Regan, Killarney (IE); Terence Cian Moloney, Cork (IE); and Francesca Giuffrida, Mezieres (CH)
Assigned to Societe des Produits Nestle S.A., Vevey (CH)
Appl. No. 16/610,271
Filed by SOCIETE DES PRODUITS NESTLE S.A., Vevey (CH)
PCT Filed May 1, 2018, PCT No. PCT/EP2018/061064
§ 371(c)(1), (2) Date Nov. 1, 2019,
PCT Pub. No. WO2018/202636, PCT Pub. Date Nov. 8, 2018.
Claims priority of application No. 17169199 (EP), filed on May 3, 2017.
Prior Publication US 2020/0245669 A1, Aug. 6, 2020
Int. Cl. A23L 33/19 (2016.01); A23J 3/08 (2006.01); A23L 33/00 (2016.01)
CPC A23L 33/19 (2016.08) [A23J 3/08 (2013.01); A23L 33/40 (2016.08); A23V 2002/00 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A method for producing a synthetic nutritional composition comprising sphingomyelin for an infant or child, the method comprising:
obtaining an α-lactalbumin enriched whey protein extract by a process comprising:
a. acidifying a first whey protein product to pH 3.3 to 3.8 by addition of an acid selected from the group consisting of hydrochloric acid, phosphoric acid, citric acid, sulfuric acid, and mixtures thereof,
b. forming a second whey protein product by concentrating proteins in the acidified first whey protein product until a calcium to protein ratio is less than about 0.001 and,
c. precipitating α-lactalbumin from the second whey protein product, wherein the precipitating includes
i. diluting the second whey protein product,
ii. adjusting a pH of the diluted second whey protein product to between 4 and to form a precipitate and soluble proteins, and
iii. separating the precipitate from the soluble proteins, wherein the precipitate is the α-lactalbumin enriched whey protein extract,
wherein the α-lactalbumin enriched whey protein extract comprises α-lactalbumin in a concentration of 28% to 40% of total protein and β-lactoglobulin in a concentration of 8% to 33% of the total protein; and
adding the α-lactalbumin enriched whey protein extract to a composition in an effective amount sufficient to obtain a final concentration of the sphingomyelin in a range found in human breast milk to obtain the synthetic nutritional composition, the composition comprising at least one of a protein source, an oil, a vitamin, or water, the synthetic nutritional composition comprises the sphingomyelin in a concentration of at least 57 mg/L, and the synthetic nutritional composition comprises the α-lactalbumin enriched whey protein extract in a concentration of 0.5 to 1.5 g/L.