US 11,656,310 B2
Real-time fMRI
Rudolf Mathias Johannes Nicolaas Lamerichs, Liempde (NL); and Stephan Heunis, Nuenen (NL)
Assigned to Koninklijke Philips N.V., Eindhoven (NL)
Appl. No. 17/297,417
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Nov. 20, 2019, PCT No. PCT/EP2019/081863
§ 371(c)(1), (2) Date May 26, 2021,
PCT Pub. No. WO2020/109095, PCT Pub. Date Jun. 4, 2020.
Claims priority of application No. 18209210 (EP), filed on Nov. 29, 2018.
Prior Publication US 2022/0034984 A1, Feb. 3, 2022
Int. Cl. G01R 33/48 (2006.01); G01R 33/50 (2006.01); G01R 33/561 (2006.01); G01R 33/563 (2006.01); A61B 5/055 (2006.01); A61B 5/00 (2006.01)
CPC G01R 33/4806 (2013.01) [A61B 5/0042 (2013.01); A61B 5/055 (2013.01); G01R 33/50 (2013.01); G01R 33/5615 (2013.01); G01R 33/56366 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of medical imaging, comprising:
receiving, fora current active time window and during a brain activity analysis session, fMRI data of a region of interest of a subject in an active state;
generating from the fMRI data a transverse relaxation, a generated T2* map using a predefined model of fMRI data variations;
comparing the generated T2* map with a reference T2* map;
estimating a blood-oxygen-level dependent (BOLD) response of the region of interest during the current active time window using results of the comparison;
receiving fMRI data obtained in a resting state period of the subject, subdividing the resting state period to a set of successive non-overlapping reference time windows, wherein a reference time window has a same length as the current active time window;
generating a T2* map for each determined reference time window and combining the generated T2* maps of each of the determined reference time windows resulting in the reference T2* map; and
excluding from the set of reference time windows a predefined subset of time windows occurring at a beginning of the resting state period, for the generating of the T2* maps, wherein a BOLD response delay from a previous active state period does not interfere with the BOLD response used for the generation of the reference T2* map.