US 11,656,206 B2
Determining mechanical properties via ultrasound-induced resonance
William F. Walker, Charlottesville, VA (US); F. Scott Corey, Baltimore, MD (US); Andrew Homyk, Charlottesville, VA (US); Tim Higgins, Charlottesville, VA (US); Francesco Viola, Charlottesville, VA (US); Frank Regan, Baltimore, MD (US); and Elisa Ferrante, Charlottesville, VA (US)
Assigned to HEMOSONICS LLC, Charlottesville, VA (US)
Filed by HEMOSONICS LLC, Charlottesville, VA (US)
Filed on Feb. 25, 2021, as Appl. No. 17/185,516.
Application 17/185,516 is a continuation of application No. 16/656,492, filed on Oct. 17, 2019, granted, now 11,002,712.
Application 16/656,492 is a continuation of application No. 15/641,803, filed on Jul. 5, 2017, granted, now 10,495,613, issued on Dec. 3, 2019.
Application 15/641,803 is a continuation of application No. 14/660,700, filed on Mar. 17, 2015, granted, now 9,726,647, issued on Aug. 8, 2017.
Prior Publication US 2021/0199622 A1, Jul. 1, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 29/44 (2006.01); G01N 29/036 (2006.01); A61B 8/08 (2006.01); G01N 29/22 (2006.01)
CPC G01N 29/4418 (2013.01) [A61B 8/0883 (2013.01); A61B 8/485 (2013.01); A61B 8/5223 (2013.01); G01N 29/036 (2013.01); G01N 29/222 (2013.01); G01N 29/4436 (2013.01); G01N 29/4472 (2013.01); G01N 2291/014 (2013.01); G01N 2291/025 (2013.01); G01N 2291/02466 (2013.01); G01N 2291/02818 (2013.01); G01N 2291/02827 (2013.01); G01N 2291/0422 (2013.01)] 20 Claims
OG exemplary drawing
1. A method for characterizing a mechanical property of a test sample, the method comprising:
transmitting a plurality of waveforms into a test chamber, including at least one forcing waveform and at least two sensing waveforms;
receiving, via at least one transducer, at least two sensing waveforms from the test chamber corresponding to the at least two transmitted sensing waveforms;
estimating, by a processor, a resonance of the test sample from the at least two received sensing waveforms; and
determining, by the processor, a modulus value associated with stiffness of a clot formed of the test sample based on the estimated resonance; and
outputting, by the processor, a hemostatic parameter derived from the determined modulus value, wherein the outputted hemostatic parameter is used to evaluate and/or treat a hemostatic dysfunction.