US 11,655,502 B2
Short pendant arm linkers for nucleotides in sequencing applications
Elena Cressina, Cambridge (GB); Antoine Francais, Cambridge (GB); and Xiaohai Liu, Cambridge (GB)
Assigned to Illumina Cambridge Limited, Cambridge (GB)
Filed by ILLUMINA CAMBRIDGE LIMITED, Cambridge (GB)
Filed on Apr. 12, 2021, as Appl. No. 17/228,477.
Application 17/228,477 is a continuation of application No. 16/732,664, filed on Jan. 2, 2020, granted, now 11,001,888.
Application 16/732,664 is a continuation of application No. 16/033,118, filed on Jul. 11, 2018, granted, now 10,526,648, issued on Jan. 7, 2020.
Claims priority of application No. 1711219 (GB), filed on Jul. 12, 2017.
Prior Publication US 2021/0230687 A1, Jul. 29, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/68 (2018.01); C07H 19/06 (2006.01); C07H 19/10 (2006.01); C07H 19/14 (2006.01); C07H 19/16 (2006.01); C07H 19/20 (2006.01); C07H 21/00 (2006.01); C07H 21/04 (2006.01); C12Q 1/6869 (2018.01); C07H 19/073 (2006.01); C12Q 1/6809 (2018.01); C12Q 1/6816 (2018.01)
CPC C12Q 1/6869 (2013.01) [C07H 19/06 (2013.01); C07H 19/073 (2013.01); C07H 19/10 (2013.01); C07H 19/14 (2013.01); C07H 19/16 (2013.01); C07H 19/20 (2013.01); C07H 21/00 (2013.01); C07H 21/04 (2013.01); C12Q 1/6809 (2013.01); C12Q 1/6816 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A compound having the structure:

OG Complex Work Unit Chemistry
wherein B is a nucleotide comprising a nucleobase and a ribose, and the 3′ OH of the ribose is protected with a 3′ blocking group;
Fl is a fluorophore attached through an optional linker; and
n is an integer from 2 to 6.