US 11,655,492 B2
Activated formylglycine-generating enzymes and methods of producing and using the same
David Rabuka, Kensington, CA (US); Gregory W. deHart, Emeryville, CA (US); Patrick Holder, Oakland, CA (US); and Jeanne Baker, Redwood City, CA (US)
Assigned to R.P. Scherer Technologies, LLC, Carson City, NV (US)
Filed by R.P. Scherer Technologies, LLC, Carson City, NV (US)
Filed on Jun. 2, 2021, as Appl. No. 17/336,975.
Application 16/866,187 is a division of application No. 16/414,202, filed on May 16, 2019, granted, now 10,683,527, issued on Jun. 16, 2020.
Application 15/862,312 is a division of application No. 14/975,403, filed on Dec. 18, 2015, granted, now 9,951,367, issued on Apr. 24, 2018.
Application 17/336,975 is a continuation of application No. 16/866,187, filed on May 4, 2020, granted, now 11,053,529.
Application 16/414,202 is a continuation of application No. 15/862,312, filed on Jan. 4, 2018, granted, now 10,344,311, issued on Jul. 9, 2019.
Claims priority of provisional application 62/134,461, filed on Mar. 17, 2015.
Claims priority of provisional application 62/112,422, filed on Feb. 5, 2015.
Prior Publication US 2022/0002775 A1, Jan. 6, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C12P 21/00 (2006.01); A61K 47/68 (2017.01); C12N 9/02 (2006.01); C07K 16/32 (2006.01); C07K 16/00 (2006.01)
CPC C12P 21/005 (2013.01) [A61K 47/68 (2017.08); A61K 47/6889 (2017.08); C07K 16/00 (2013.01); C07K 16/32 (2013.01); C12N 9/0051 (2013.01); C12P 21/00 (2013.01); C07K 2317/14 (2013.01); C07K 2317/40 (2013.01); C12Y 108/99 (2013.01)] 10 Claims
 
1. An activated formylglycine-generating enzyme (FGE) produced by a method comprising treating an FGE with Cu2+ to produce an activated FGE.