US 11,655,343 B2
Alginate hydrogel compositions
Venkata R. Garigapati, Southborough, MA (US); Tetsuo Hoshino, Arlington, MA (US); and Amit Garle, Lowell, MA (US)
Assigned to Takeda Pharmaceutical Company Limited, Osaka (JP)
Appl. No. 16/86,405
Filed by Takeda Pharmaceutical Company Limited, Osaka (JP)
PCT Filed Mar. 21, 2017, PCT No. PCT/US2017/023371
§ 371(c)(1), (2) Date Sep. 19, 2018,
PCT Pub. No. WO2017/165389, PCT Pub. Date Sep. 28, 2017.
Claims priority of provisional application 62/312,998, filed on Mar. 24, 2016.
Prior Publication US 2019/0100628 A1, Apr. 4, 2019
Int. Cl. C08J 3/075 (2006.01); C08B 37/00 (2006.01); C08J 3/24 (2006.01); C08L 5/04 (2006.01); C08L 71/02 (2006.01); C12N 5/00 (2006.01); C12N 5/0783 (2010.01); C12N 5/078 (2010.01); C12N 5/0775 (2010.01)
CPC C08J 3/075 (2013.01) [C08B 37/0084 (2013.01); C08J 3/245 (2013.01); C08L 5/04 (2013.01); C08L 71/02 (2013.01); C12N 5/0018 (2013.01); C08J 2305/04 (2013.01); C08L 2203/02 (2013.01); C12N 5/0636 (2013.01); C12N 5/0644 (2013.01); C12N 5/0662 (2013.01)] 17 Claims
 
1. A semi-permeable hydrogel composition comprising an alginate that forms an alginate matrix comprising a periphery, wherein the periphery of the alginate matrix is covalently crosslinked to a multi-armed water soluble polymer that comprises polyethylene glycol or poly(2-methacryloyloxy ethyl phosphorylcholine), wherein the multi-armed water soluble polymer forms a covalently crosslinked surface layer on the alginate matrix, and wherein the covalent crosslink of the multi-armed water soluble polymer and the alginate comprises a linkage that is a product of a first click-reactive functional group of the multi-armed water soluble polymer and a second click-reactive functional group of the alginate.