US 11,655,302 B2
Anti-CD38 antibodies and formulations
Marielle Chiron Blondel, Paris (FR); Cendrine Lemoine, Paris (FR); Angela Virone-Oddos, Paris (FR); Béatrice Cameron, Paris (FR); Jacques Dumas, Paris (FR); Alain Fournier, Paris (FR); Jonathan Kingsbury, Bridgewater, NJ (US); Brian Murray, Bridgewater, NJ (US); Nathan Ostberg, Bridgewater, NJ (US); Sanket Patke, Bridgewater, NJ (US); and Zichuan Zhang, Bridgewater, NJ (US)
Assigned to SANOFI, Paris (FR)
Filed by SANOFI, Paris (FR)
Filed on Jun. 9, 2020, as Appl. No. 16/896,784.
Claims priority of provisional application 62/859,699, filed on Jun. 10, 2019.
Claims priority of application No. 20305146 (EP), filed on Feb. 17, 2020.
Prior Publication US 2020/0399391 A1, Dec. 24, 2020
Int. Cl. C07K 16/28 (2006.01); A61K 47/26 (2006.01); A61K 9/19 (2006.01); A61K 47/18 (2017.01)
CPC C07K 16/2896 (2013.01) [A61K 9/19 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); C07K 2317/72 (2013.01); C07K 2317/732 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01)] 24 Claims
 
1. An antibody that specifically binds human CD38, wherein the antibody comprises
a) a heavy chain (HC) having an amino acid sequence of SEQ ID NO: 2 and a light chain (LC) having an amino acid sequence of SEQ ID NO: 7, or
b) a heavy chain (HC) having an amino acid sequence of SEQ ID NO: 3 and a light chain (LC) having an amino acid sequence of SEQ ID NO: 7, or
c) a heavy chain (HC) having an amino acid sequence of SEQ ID NO: 4 and a light chain (LC) having an amino acid sequence of SEQ ID NO: 7, or
d) a heavy chain (HC) having an amino acid sequence of SEQ ID NO: 5 and a light chain (LC) having an amino acid sequence of SEQ ID NO: 8, or
e) a heavy chain (HC) having an amino acid sequence of SEQ ID NO: 5 and a light chain (LC) having an amino acid sequence of SEQ ID NO: 9, or
f) a heavy chain (HC) having an amino acid sequence of SEQ ID NO: 6 and a light chain (LC) having an amino acid sequence of SEQ ID NO: 8, or
g) a heavy chain (HC) having an amino acid sequence of SEQ ID NO: 6 and a light chain (LC) having an amino acid sequence of SEQ ID NO: 9.