US 11,655,265 B2
Method for preparing L-glufosinate
Yongjiang Liu, Sichuan (CN); Jie Cai, Sichuan (CN); Min Xu, Sichuan (CN); Tingying Liu, Sichuan (CN); Lei Zhou, Sichuan (CN); Wei Zeng, Sichuan (CN); Ke Cheng, Sichuan (CN); and Yingsui Yin, Sichuan (CN)
Assigned to Lier Chemical Co., Ltd., Sichuan (CN); and Guangan Lier Chemical Co., Ltd, Sichuan (CN)
Filed by Lier Chemical Co., Ltd., Sichuan (CN); and Guangan Lier Chemical Co., Ltd., Sichuan (CN)
Filed on Jun. 15, 2022, as Appl. No. 17/841,410.
Application 17/841,410 is a continuation of application No. PCT/CN2021/107238, filed on Jul. 20, 2021.
Claims priority of application No. 202011093594.7 (CN), filed on Oct. 14, 2020.
Prior Publication US 2022/0324888 A1, Oct. 13, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C07F 9/30 (2006.01); C07F 9/48 (2006.01); C07F 9/50 (2006.01); C07F 9/535 (2006.01); C07F 9/6584 (2006.01)
CPC C07F 9/301 (2013.01) [C07F 9/4883 (2013.01); C07F 9/5004 (2013.01); C07F 9/535 (2013.01); C07F 9/65844 (2013.01)] 29 Claims
 
1. A method for preparing L-glufosinate (I), wherein the method comprises the following steps:

OG Complex Work Unit Chemistry
a) preparing a compound of Formula (III) from a compound of Formula (II), and

OG Complex Work Unit Chemistry
b) preparing L-glufosinate from the compound of Formula (III),
wherein:
X is halogen;
Y is —OR1 or —N(R2)(R3);
R1, R2 and R3 are each independently substituted or unsubstituted alkyl having 1-6 carbon atoms, substituted or unsubstituted alkenyl having 2-6 carbon atoms, substituted or unsubstituted alkynyl having 2-6 carbon atoms, substituted or unsubstituted cycloalkyl having 3-10 carbon atoms, substituted or unsubstituted aryl having 6-20 carbon atoms, substituted or unsubstituted heteroaryl having 2-10 carbon atoms, or —Si(R4)(R5)(R6);
R4, R5 and R6 are each independently substituted or unsubstituted alkyl having 1-6 carbon atoms, or substituted or unsubstituted aryl having 6-20 carbon atoms; and
substituents for the alkyl, alkenyl, alkynyl, cycloalkyl, aryl and heteroaryl groups are each independently halogen, carboxyl, amino, nitro, cyano, alkyl having 1-6 carbon atoms, aryl having 6-10 carbon atoms, or cycloalkyl having 3-10 carbon atoms.